The workflow. Samples were divided into patients with favorable and unfavorable prognosis according to their time of recurrence (time period of relapse after the first event of breast cancer, denoted in years) and event of metastasis (favorable: time recurrence above 5 years, unfavorable: time recurrence of less than three years and the occurrence of metastasis). Expression data were mapped onto the reactions from KEGG and analyzed. Pathways with significant expression patterns were ranked according to the significance of the patterns and compared with the literature.
Schramm et al. BMC Medical Genomics 2010 3:39 doi:10.1186/1755-8794-3-39