Table 4 |
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|
Over-represented Panther biological processes in modules correlated to a metabolic trait in subcutaneous (SAT) and visceral adipose tissue (VAT) |
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|
SAT Module 4 |
SAT Module 8 |
VAT Module 9 |
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|
|
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|
No. of genes in module |
P-value |
No. of genes in module |
P-value |
No. of genes in module |
P-value |
|
|
|
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|
Total |
308 |
87 |
103 |
|||
|
Signal transduction |
67 |
2.8 × 10-4 |
NA |
NS |
NA |
NS |
|
- Intracellular signalling cascade |
26 |
2.0 × 10-3 |
NA |
NS |
NA |
NS |
|
Immunity and defense |
43 |
3.5 × 10-9 |
31 |
4.1 × 10-17 |
21 |
8.2 × 10-7 |
|
- T-cell-mediated immunity |
13 |
9.2 × 10-5 |
7 |
6.4 × 10-4 |
NA |
NS |
|
- MHCII-mediated immunity |
NA |
NS |
5 |
2.5 × 10-5 |
NA |
NS |
|
- Macrophage-mediated immunity |
NA |
NS |
7 |
7.5 × 10-5 |
5 |
3.3 × 10-2 |
|
- Endocytosis |
NA |
NS |
7 |
6.2 × 10-3 |
NA |
NS |
|
- B-cell and antibody-mediated immunity |
7 |
2.4 × 10-2 |
4 |
4.9 × 10-2 |
NA |
NS |
|
- Complement mediated immunity |
NA |
NS |
4 |
2.4 × 10-3 |
NA |
NS |
|
Transport |
41 |
2.8 × 10-7 |
NA |
NS |
16 |
1.2 × 10-3 |
|
- Ion transport |
23 |
1.8 × 10-4 |
NA |
NS |
NA |
NS |
|
Cell adhesion |
20 |
1.6 × 10-3 |
NA |
NS |
11 |
9.2 × 10-4 |
|
Lipid, fatty acid and steroid metabolism |
21 |
9.7 × 10-3 |
NA |
NS |
NA |
NS |
|
Carbohydrate metabolism |
19 |
2.5 × 10-3 |
NA |
NS |
NA |
NS |
|
Other |
89 |
NA |
37 |
NA |
44 |
NA |
|
Unclassified |
76 |
NA |
19 |
NA |
24 |
NA |
|
|
||||||
|
SAT modules 4 and 8 correlate to HDL, and VAT module 9 correlates to glucose. The modules SAT 12, SAT 39, VAT 40 do not contain enough genes to perform a reliable pathway analysis. The modules correlated to gender in both tissues consist solely of Y-chromosomal genes and are not included in the table. Only biological functions that are over-represented in a module after Bonferroni correction are shown. For each over-represented biological function the number of genes in the module that belong to this biological function, and the corresponding Bonferroni corrected p-value for over-representation are shown. The number of genes that are part of a class which is not over- or under-represented, and the number of genes that could not be classified by PANTHER are also shown for each module ("other" and "unclassified" respectively). NA, not applicable; NS, not significant. |
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|
Wolfs et al. BMC Medical Genomics 2010 3:34 doi:10.1186/1755-8794-3-34 |
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