Table 4

Over-represented Panther biological processes in modules correlated to a metabolic trait in subcutaneous (SAT) and visceral adipose tissue (VAT)

SAT Module 4

SAT Module 8

VAT Module 9


No. of genes in module

P-value

No. of genes in module

P-value

No. of genes in module

P-value


Total

308

87

103

Signal transduction

67

2.8 × 10-4

NA

NS

NA

NS

- Intracellular signalling cascade

26

2.0 × 10-3

NA

NS

NA

NS

Immunity and defense

43

3.5 × 10-9

31

4.1 × 10-17

21

8.2 × 10-7

- T-cell-mediated immunity

13

9.2 × 10-5

7

6.4 × 10-4

NA

NS

- MHCII-mediated immunity

NA

NS

5

2.5 × 10-5

NA

NS

- Macrophage-mediated immunity

NA

NS

7

7.5 × 10-5

5

3.3 × 10-2

- Endocytosis

NA

NS

7

6.2 × 10-3

NA

NS

- B-cell and antibody-mediated immunity

7

2.4 × 10-2

4

4.9 × 10-2

NA

NS

- Complement mediated immunity

NA

NS

4

2.4 × 10-3

NA

NS

Transport

41

2.8 × 10-7

NA

NS

16

1.2 × 10-3

- Ion transport

23

1.8 × 10-4

NA

NS

NA

NS

Cell adhesion

20

1.6 × 10-3

NA

NS

11

9.2 × 10-4

Lipid, fatty acid and steroid metabolism

21

9.7 × 10-3

NA

NS

NA

NS

Carbohydrate metabolism

19

2.5 × 10-3

NA

NS

NA

NS

Other

89

NA

37

NA

44

NA

Unclassified

76

NA

19

NA

24

NA


SAT modules 4 and 8 correlate to HDL, and VAT module 9 correlates to glucose. The modules SAT 12, SAT 39, VAT 40 do not contain enough genes to perform a reliable pathway analysis. The modules correlated to gender in both tissues consist solely of Y-chromosomal genes and are not included in the table.

Only biological functions that are over-represented in a module after Bonferroni correction are shown. For each over-represented biological function the number of genes in the module that belong to this biological function, and the corresponding Bonferroni corrected p-value for over-representation are shown. The number of genes that are part of a class which is not over- or under-represented, and the number of genes that could not be classified by PANTHER are also shown for each module ("other" and "unclassified" respectively). NA, not applicable; NS, not significant.

Wolfs et al. BMC Medical Genomics 2010 3:34   doi:10.1186/1755-8794-3-34

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