Table 4

Biological processes of genes differentially expressed in CD34+ and stromal cells from MDS-RARS patients.

Genes Differentially Expressed


Biological Process1

in CD34+ Cells

in Stromal Cells


apoptosis

CYFIP2, ↓MGC29506, ↑PHLDA2, ↑SGK1, ↓SOCS2, ↓TNFRSF21, ↑TNFRSF1B, ↓UNC13B

___________

blood coagulation

SEC63, ↑SERPINA1

___________

cell adhesion

AEBP1, ↓COL5A1, ↓CYFIP2, ↑ITGAX, ↓JAM2, ↓LAMB2, ↓LAMC1, ↓PCDH9, ↓PDZD2, ↓ROBO1, ↑VCAN

RGMB

cell cycle

E2F7, ↓NASP, ↓UHRF1

____________

cell differentiation

NAV1, ↓ROBO1

SEMA3A

cell motility

____________

SPINT2

cell proliferation

CD81, ↓DLG3, ↓FLT3, ↑LRP1, ↓NASP, ↓NPY, ↑S100A11, ↓UHRF1, ↑VEGFA

____________

DNA replication

____________

KRT7

exocytosis

NKD2, ↓RIMS3, ↓UNC13B

____________

immune response

CD19, ↑CTSS, ↓ERAP1, ↑OAS1, ↓PXDN

HLA-E

inflammatory response transport

AOAH, ↓C5, ↓BLNK, ↑LY96

____________

ABCB7, ↓COL5A1, ↑HVCN1, ↓KCNE1L, ↓KCNMB3, ↓KCNMB4, ↓NKD2, ↓NPY, ↑SGK1, ↑SGSH, ↑SLC8A1, ↑SLC11A2, ↓SLC12A2, ↑SLC37A2, ↓SLC39A8, ↑SLC43A2

SCFD2, ↓GRIA3

oxidation reduction

AASS, ↑CYB5R1, ↑IFI30, ↓PTGR1, ↓PXDN

LEPREL1

protein amino acid phosphorylation

FLT3, ↑HCK, ↑SGK1

↓TNIK

regulation of transcription

ECHDC2, ↓AEBP1, ↓AFF3, ↓BACH2, ↓CEP290, ↓E2F7, ↓EBF1, ↓ELP2, ↑ETV3, ↑JAZF1, ↓LOC400713, ↑NCOA4, ↑NR4A2, ↑NR4A3, ↓POU2AF1, ↑RXRA, ↓TLE1, ↓UHRF1, ↓ZNF711, ↓ZNF91

___________

rRNA processing

____________

___________

signal transduction

ANK3, ↑ARHGEF10L, ↓C13orf18,↑NR4A2, ↓PSD3, ↑S100A11, ↓TLE1, ↓TNFRSF21

____________

others

AADACL1, ↓AADAT, ↑ACPP, ↓ACSM3, ↑ADCY7, ↓AHI1, ↓ALS2CR4, ↓AUTS2, ↓C16orf67, ↓C1orf21, ↓C9orf58, ↑CALML4, ↓CCDC136, ↓CLIP3, ↑COLT1, ↑CTSH, ↓CYYR1, ↑DDX3X, ↑DDX3Y, ↓DPY19L2, ↓EBF1, ↑EHBP1L1, ↓FAAH, ↑FGD6, ↑FGFR1OP2, ↓HHAT, ↓HS3ST1, ↑IL10RA, ↑JHDM1D, ↓LAYN, ↑LFNG, ↓LRIG1, ↓MMP11, ↓MPDZ, ↓MYO1D, ↓MYO5C, ↓NEIL1, ↓PLS3, ↓SH2D4B, ↓SNORA71B, ↓SPATS2, ↓ST7OT1, ↓TMEM217, ↓TOP2B, ↑TSPAN14, ↓TSPYL5, ↓UQCC, ↑WIPI1

___________


1The biological processes categories were obtained from the GOA database. Genes (↑) up-regulated or (↓) down-regulated in MDS-RARS patients with respect to healthy individuals.

Baratti et al. BMC Medical Genomics 2010 3:30   doi:10.1186/1755-8794-3-30

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