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Open Access Technical advance

Pathway analysis comparison using Crohn's disease genome wide association studies

David Ballard1*, Clara Abraham2, Judy Cho23 and Hongyu Zhao34

Author Affiliations

1 Robert S. Boas Center for Human Genetics and Genomics, Feinstein Institute for Medical Research, Manhasset, New York, USA

2 IBD Center, Division of Gastroenterology, Department of Medicine, Yale University, New Haven, CT, USA

3 Department of Genetics, Yale University, New Haven, CT, USA

4 Department of Epidemiology and Public Health, Yale University, New Haven, CT, USA

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BMC Medical Genomics 2010, 3:25  doi:10.1186/1755-8794-3-25

Published: 28 June 2010

Additional files

Additional file 1:

Significant pathways from Random Set analysis. The table lists the significant pathways across dataset (WTCCC, Jewish, non-Jewish) and IL23R status (included, excluded, conditioned upon). An 'X' means the pathway had an FDR less than 0.01.

Format: XLSX Size: 12KB Download file

Open Data

Additional file 2:

Genes located in significant pathways across three datasets. The table lists the genes located in the two pathways 'IL-2' and 'IL-9' which were significant in each dataset evaluated. across dataset (WTCCC, Jewish, non-Jewish) and IL23R status (included, excluded, conditioned upon). An 'X' means the pathway had an FDR less than 0.01. Each gene is followed by the p-value obtained from PCA regression of disease status onto SNPs located within the gene.

Format: XLSX Size: 19KB Download file

Open Data

Additional file 3:

Significant pathways from Binomial analysis. The table lists the significant pathways across dataset (WTCCC, Jewish, non-Jewish) and IL23R status (included, excluded, conditioned upon). An 'X' means the pathway had an FDR less than 0.01.

Format: XLSX Size: 12KB Download file

Open Data