Table 4

Graffi-virus integration sites in the megakaryoblastic leukaemias

Sample

Chromosome

Genome

Upstream genes*

Integra-tion within a gene

Downstream genes*


gene 1

kb

gene 2

kb

gene 1

kb

gene 2

kb


Mk1

1D

93018002

Gm817

17

Lrrfip1

60

    Ramp1
**

Ube2f

95

Scly

130

1G2

153451217

Rnf2

188

1190005F20Rik

230

Niban

Edem3

92

Q8K3Do

199

4B1

41816941

2310028H24Rik

133

1700066J25Rik

138

Dnaic1

Cntfr

29

Dcnt3

86

5E 1

75741720

Pdgfra

216

Gsh2

382

-

    Kit
**

114

Kdr

472

6F3

128801887

Klrb1b

10

Clec2h

159

-

Clec21

50

Klrb1f

208

6G1

135264443

Gsg1

61

Hebp1)

130

-

Pbp2

10

Dynlt1

50

11B4

70471623

    Pfn1
**

0.8

Rnf167

4

-

Eno3

1.7

Spag7

8.2

11B5

80139013

Rhot1

55

Rnf135

123

Rhbd13

Zfp207

60

Psmd11

105

15D3

62283939

Pvt1

211

    Myc
**

463

-

-

15F2

95582212

Dbx2

100

Nell2

225

-

-

Tmem16f

36

16B3

33700976

Heg1

13

Slc12a8

118

-

Muc13

12

    Itgb5
**

48

Mk2

1 E4

132543823

Pfkb2

0.4

C4bp

54

-

Yod1

0.8

AA986890

1

6A3

25759728

Pot 1a

14

Grp37

120

-

-

-

8 E1

123703449

Irf8

81

Cox4i1

149

-

    Foxf1a
**

269

Mthfsd

280

12C1

52786246

Hectd1

120

EG544864

35

-

Heatr5a

11

6530401NO4Rik

124

13D2.3

116255725

Pelo

46

Itga1

33

-

-

-

Mk3

1C5

Glrp1

146

Spp2

230

-

Arl14c

161

Sh3bp4

413

1F

139621937

-

-

Ptprc

257

Atp6v1g3

466

2H3

165618991

    Prkcbp1
**

43

Eya2

156

-

Ncoa3

65

Sulf2

146

5B1

43941

Rheb

23

Cryng

83

-

    Prkag2
**

20

1500035N22Rik

144

6D2

88086902

Rpn1

16

EG434064

115

-

    Gata2
**

72

Dnajb8

100

7B4

45356428

Bax

21

Flt1

28

Dhdh

Nucb1

4

Tulp2

25

7F5

144856850

    Ccnd1
**

107

Oraov1

167

-

Tpcn2)

167

Mrgprf

253

13A1

3830652

Calm13

27

-

Calm4

6

Calm5

22

14C3

53491694

Prmt5

20

Rem2

57

-

D14Ertd500e

4

Jub

31

19A

4301566

Ankrd13d

18

Ssh3

32

    Adrbk1
**

Fbxl13

15

FBXL13

15


* the 2 most proximal genes located at a maximum distance of 500kb upstream (5') or downstream (3') of the integration site

** genes present in the RTCGD database

Voisin et al. BMC Medical Genomics 2010 3:2   doi:10.1186/1755-8794-3-2

Open Data