Table 2

Genes over-expressed in the megakaryoblastic leukaemias

Probeset

Gene

SAM results

Leukaemic samples *

GSE 6593

d-score

p-value

FDR

T1

T2

T3

B1

B2

B3

M

E1

E2

E3

Mk1

Mk2

Mk3


Genes potentially implicated in the disease **

Mk

1443260_at

Meis1

12.0

<0.001

0.1

-1.5

-1.3

-1.7

-1.5

-1.3

-1.7

-1.4

-1.4

-1.3

-1.3

4.5

5.9

4.0

ND

1428647_at

Pbx1

10.2

<0.001

0.07

-1.6

-1.1

-1.1

-1.3

-1.3

-1.6

-1.2

-1.2

-1.1

-1.4

4.3

5.3

3.3

ND

1417155_at

Nmyc

16.0

<0.001

0.08

-2.0

-1.6

-1.9

-0.7

-0.6

-1.2

-1.6

-1.8

-1.5

-1.9

4.8

5.6

4.4

NS

1451332_at

Evi3

13.0

<0.001

0.08

-1.1

-1.3

-1.1

-1.1

-1.0

-0.9

-0.7

-0.7

-0.6

-0.9

3.5

3.3

2.6

NS

1441350_at

Fgf3

5.4

0.002

0.12

-0.7

-0.7

-0.6

-0.6

-0.7

-0.8

-0.6

-0.4

-0.6

-0.5

1.3

2.9

1.9

1417552_at

Fap

7.2

<0.001

0.09

-1.7

-1.6

-1.7

-1.8

-1.7

-1.7

-1.7

-1.5

-1.6

-1.4

5.9

7.0

3.6

ND

1438325_at

Evi1

4.5

0.005

0.16

-1.8

-0.9

-1.4

-1.7

-1.7

-1.4

-1.8

-1.1

-1.4

-1.5

7.3

2.4

4.8

ND

1440964_s_at

Cbfa2t3h

11.0

<0.001

0.08

-0.4

-0.7

-1.1

-0.3

-0.6

-0.3

-0.1

0.2

-0.6

-0.2

1.4

1.4

1.2

NS

MkE1

1452072_at

Myct1

7.2

<0.001

0.07

-2.0

-1.7

-1.7

-1.6

-1.5

-1.6

-1.4

2.0

-1.1

0.6

3.0

4.5

2.5

NS

MkMB

1437247_at

FosL2

10.3

<0.001

0.01

-0.8

-0.5

-0.8

-0.7

-0.7

-0.8

1.8

-0.5

-0.5

-0.6

1.6

1.6

0.8

ND

1417409_at

Jun

5.1

<0.001

0.03

-0.3

-1.4

-3.3

1

1.1

1.4

4.1

-1.3

-1.5

-2.3

0.8

0.8

0.91

1434705_at

Ctbp2

15.3

<0.001

0.01

-1.1

-1.0

-1.6

-0.9

-1.1

-1.3

3.2

-1.2

-1.4

-1.9

3.3

2.7

2.4

NS

1452514_a_at

Kit

10.5

<0.001

0.01

-2.2

-2.1

-2.2

-2.2

-2.3

1.2

2.8

-1.7

-1.6

-2.2

3.8

4.6

4.0

1418747_at

Sfpi1

9.9

<0.001

<0.01

-2.6

-1.7

-1.7

1.4

0.9

1.1

3.0

-1.7

-1.4

-1.8

1.2

2.1

1.1

1452410_a_at

Fes

10.2

<0.001

<0.01

-2.3

-1.7

-1.7

1.8

0.5

1.0

3.0

-1.4

-2.0

-1.9

1.4

2.2

1.1

1428669_at

Bmyc

5.8

<0.001

0.04

0.8

-0.9

0.9

-1.5

-1.2

-0.5

1.3

-1.6

-1.2

-1.4

1.7

2.2

1.4

1420710_at

Rel

5.8

<0.001

0.02

-0.4

0.0

-0.8

0.4

1.0

0.9

1.0

-0.9

-1.3

-1.1

0.6

-0.1

0.6

NS

Genes potentially implicated in inflammation response

MkMB

1449222_at

Ebi3

11.2

<0.001

0.01

-1.4

-1.3

-1.2

-1.4

-1.2

-1.3

3.6

-0.7

-1.1

-1.6

2.2

3.1

2.23

1418262_at

Syk

1.6

<0.001

<0.01

-2.4

-2.5

-2.8

2.8

2.4

2.6

1.5

-1.6

-2.2

-2.8

1.4

1.6

1.96

NS

1419132_at

Tlr2

6.7

<0.001

0.01

-0.8

-1.4

-1.6

0.6

0.1

0.6

2.4

-0.9

-1.4

-1.5

1

2

0.9

1418163_at

Tlr4

6.3

<0.001

0.01

-1.8

-1.6

-1.4

0.5

1.8

2.2

2.5

-1.2

-0.8

-1.3

0.4

0.7

0.0

ND

1456046_at

C1qr1

8.1

<0.001

<0.01

-2.2

-3.7

-4.2

4.1

3.9

4.1

3.7

-2.3

-2.2

-4.1

0.9

0.6

1.4

ND

Genes selected for RT-PCR validation

1434141_at

Gucy1a3

18.2

<0.001

0.07

-1.2

-0.6

-1.0

-1.0

-1.1

-1.2

-1.0

0.2

-1.1

-1.0

3.0

3.2

2.7

-

1437687_x_at

Fkbp9

23.7

<0.001

0.07

-1.4

-1.3

-1.6

-1.3

-1.3

-1.3

-1.1

-1.0

-1.0

-1.1

4.1

4.6

3.9

NS

1453771_at

Gulp1

14.2

<0.001

0.07

-0.7

-0.7

-0.5

-0.6

-0.9

-0.9

-0.9

-1.0

-0.9

-0.9

3.1

2.6

2.3

-

1448561_at

Ncf2

18.5

<0.001

<0.01

-2.6

-2.4

-2.1

2.0

1.6

1.6

3.0

-2.1

-2.2

-2.4

1.6

2.5

1.6

NS

1450333_a_at

Gata2

7.4

<0.001

0.01

-2.3

-2.0

-2.3

-2.1

-2.4

-1.9

-1.6

0.2

2.4

1.1

3.6

4.0

3.4


* amplitude of deviation from the mean calculated from the RMA values

** cell cycle/cell growth/development/angiogenesis/DNA repair/transcription regulation

ND (not determined), NS (not significant)

Voisin et al. BMC Medical Genomics 2010 3:2   doi:10.1186/1755-8794-3-2

Open Data