Table 1

Genes specific to the erythroid and megakaryoblastic leukaemias

probeset

gene

SAM results *

Leukaemic samples**

d-score

FDR

T1

T2

T3

B1

B2

B3

M

E1

E2

E3

Mk1

MK2

Mk3


Fibrinogen receptor and related genes

1417758_at

Itga2b

10.58

<0.001

-2.7

-1.6

-2.6

-2.9

-2.6

-2.7

-1.6

3.8

0.8

1.1

3.6

3.6

3.8

1421511_at

Itgb3

-

>0.01

-1.0

-0.7

-0.7

-0.8

-0.7

-0.9

-0.6

1.6

-0.7

-0.7

-0.6

2.9

3.1

1416066_at

Cd9

5.5

0.002

1.1

-2.5

2.5

-3.5

-3.6

-3.6

0.6

1.9

-1.8

-2.1

3.0

4.4

3.5

1456085_x_at

Cd151

7.56

<0.001

-1.2

-1.1

-0.7

-0.7

-0.9

-0.6

-0.3

1.4

-0.2

-0.3

1.8

0.8

2.1

1420558_at

Selp

12.03

<0.001

-1.0

-1.2

-1.9

-1.6

-1.5

-1.7

-1.1

-0.9

-1.7

-1.6

4.3

5.7

4.1

1457782_at

Tln1

7.19

<0.001

-0.7

-0.4

-1.4

-0.3

-0.8

-1.0

0.9

2.3

-1.5

-0.5

0.8

1.4

1.3

1424595_at

F11r

5.58

0.002

-0.9

-0.8

-0.9

-0.8

-0.6

-1.0

-0.6

0.2

-0.6

-0.6

2.0

3.1

1.5

1451097_at

Vasp

5.24

<0.001

-0.8

-1.3

0.1

0.3

-0.3

0.3

0.7

0.0

-0.6

-1.0

0.8

1.2

0.7

1418261_at

Syk

16.04

<0.001

-2.4

-2.8

-2.8

2.9

2.5

2.8

1.4

-1.5

-2.0

-3.1

1.5

1.6

1.8

1455349_at

Rap1b

4.63

<0.001

-0.7

-0.8

-1.1

-0.6

-1.2

-1.0

-0.2

2.1

-0.3

0.9

0.7

0.9

1.4

Heme biosynthesis

1451675_a_at

Alas2

8.85

<0.001

-3.4

0.3

-0.9

-2.5

-3.8

-3.2

-1.3

4.9

4.9

4.8

-2.8

-0.5

3.5

1424877_a_at

Alad

8.91

<0.001

-1.2

-0.4

0.0

-1.3

-1.6

-0.7

-1.6

2.2

2.2

2.0

0.4

-0.9

1.2

1426475_at

Hmbs

13.44

<0.001

-1.2

-1.0

-0.4

-1.5

-1.1

-1.1

-1.1

2.6

3.4

2.7

-0.8

-0.9

0.5

1423482_at

Uros

-

-

-0.6

-0.3

-0.2

-0.3

0.1

0.2

-0.9

0.7

1.5

0.2

0.0

-0.5

0.0

1417206_at

Urod

10.87

<0.001

0.0

-0.4

-0.3

-1.2

-0.9

-1.0

-0.3

1.8

1.6

1.4

-0.6

-0.5

0.3

1422493_at

Cpox

22.18

<0.001

-1.6

-1.2

-0.2

-0.5

-0.8

-1.0

-1.5

2.7

3.1

3.2

-1.0

-0.7

-0.4

1416618_at

Ppox

4.58

0.004

-0.5

-0.1

-0.3

0.1

-0.2

-0.4

0.0

0.7

1.4

0.6

-0.6

-0.4

-0.4

1418699_s_at

Fech

8.61

<0.001

-0.7

-1.0

-0.3

-1.9

-1.9

-2.0

-0.4

2.5

3.1

2.2

-0.7

0.0

1.1

Erythroid and megakaryoblastic transcription factors

EMk

1450333_a_at

Gata2

7.4

0.01

-1.9

-1.6

-1.9

-1.7

-1.8

-1.9

-1.1

-0.6

2.2

0.6

3.4

3.4

2.8

1423603_at

Zfpm1(Fog1)

5.4

0.02

-1.2

-1.7

-1.4

0.1

-0.6

-0.2

-3.9

2.0

2.0

2.0

1.3

0.8

0.9

1449389_at

Scl/Tal1

20.8

<0.01

-3.3

-2.5

-3.1

-3.2

-2.5

-2.5

-2.5

4.1

3.8

3.5

2.6

2.9

2.9

1454086_a_at

Lmo2

4.5

0.03

-5.1

-3.8

-4.6

0.7

-1.3

-0.9

0.7

2.8

3.0

2.9

1.3

2.5

1.8

1452001_at

Nfe2

8.3

0.01

-4.2

-3.0

-3.4

-3.8

-3.0

-3.2

1.3

3.7

3.5

3.3

2.5

3.7

2.8

EMk3

1449232_at

Gata1

4.6

0.03

-1.9

-1.9

-2.1

-2.1

-2.3

-2.7

-1.9

4.5

4.1

4.5

0.6

-1.4

2.5

MkE1

1441584_at

Fli1

5.3

0.1

-0.2

-0.4

-0.5

0.7

0.6

0.5

0.7

2.6

-4.8

-4.9

1.8

2.4

1.6

Erythroid transcription factors

EMk3

1418600_at

Klf1

6.8

0.04

-2.9

-2.3

-2.4

-2.7

-2.7

-2.8

-1.8

4.8

5.4

5.3

1.7

-1.7

2.1

1419311_at

Trim10

8.9

0.02

-2.0

-1.4

-2.1

-2.1

-2.1

-2.0

-1.5

5.0

4.1

3.8

-1.0

-0.8

2.1

Megakaryoblastic transcription factors

MkE1

1421461_at

Mpl

16.1

<0.001

0.07

-1.9

-1.6

-2.1

-2.0

-2.1

-2.0

-1.3

1.3

-1.0

-1.7

4.9

4.4

MkE1

1440878_at

Runx1

4.5

0.11

0.6

-1.8

-1.0

0.2

0.2

0.5

-0.5

0.9

-0.8

-0.1

0.7

0.8

0.3


* SAM p-value less than 0,001 for every sample

** amplitude of deviation from the mean calculated from the RMA values

Voisin et al. BMC Medical Genomics 2010 3:2   doi:10.1186/1755-8794-3-2

Open Data