Table 4

Proteins with high cross-talk ranking values at different time stages.

Duration

Top ranked proteins


0~1HR

IRAK1

NIK

IKKα

TRAF6

IKKβ

1~2HR

TRAF6

IRAK1

NIK

A20

TRAF2

2~3HR

IRAK1

TRAF6

NIK

A20

TRAF2

3~4HR

IRAK1

NIK

TRAF6

A20

IKKγ

4~6HR

IRAK1

TRAF6

NIK

TRAF2

A20

6~8HR

IRAK1

NIK

TRAF6

IKKα

A20


In contract with Table 2, proteins with maximal CTRVs are listed here. Among these highly ranked proteins, NIK and A20 are considered as two core elements in the signaling network by the analysis of CTRV, but their importance is not exhibited in Table 2. This reveals that our proposed method generates a new insight into the evaluation of cross-talk candidates.

Yang et al. BMC Medical Genomics 2010 3:19   doi:10.1186/1755-8794-3-19

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