Table 2

Statistics of the TNFα-induced protein-protein association networks of HUVEC.

Duration

Nodes

Edges

Highly connected proteins


0~1HR

56

144

TRAF2

IRAK1

TRAF6

IKKα

IKKβ

1~2HR

56

156

TRAF2

TRAF6

IRAK1

RIP

TNFR1

2~3HR

56

150

IRAK1

TRAF6

TRAF2

IKKα

RIP

3~4HR

55

152

TRAF2

IKKα

TNFR1

IRAK1

TRAF6

4~6HR

56

151

IRAK1

TRAF2

TRAF6

RIP

TNFR1

6~8HR

56

156

TRAF2

TRAF6

RIP

IKKα

IRAK1


Summary of the reconstruction of protein-protein association networks at different time stages. Proteins with maximal protein-protein associations are sorted in this table. These proteins are usually considered as the hubs which will be involved in several biological functions and play important roles in the signaling network.

Yang et al. BMC Medical Genomics 2010 3:19   doi:10.1186/1755-8794-3-19

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