Counting for the cross-talk ranking values (CTRVs). CTRV is a ranking value which reflects the potential of a protein in connection with multiple pathways. (A) All proteins connected with protein A belong to the same pathway A. In this case, the CTRV of protein A will not be changed. (B) If protein A connects with protein B, which belongs to a different pathway, then both CTRVs of protein A and B will be added by one.
Yang et al. BMC Medical Genomics 2010 3:19 doi:10.1186/1755-8794-3-19