Table 4

Prediction of environmental chemicals associated with breast cancer samples (GSE6883).

Chemical Predicted

Hypergeometric P-value

Rank (percentile)

q-value

Relevant genes in set (number of references)

Citations


Progesterone

2 × 10-4

6 (99)

0.01

IL6(3), STC1(3), CEBPD(2)

[64,65]


Genistein

6 × 10-4

10 (99)

0.03

CEBPD(1), APLP2(1), MLF1(1)

[66-68]


Estradiol

7 × 10-4

11 (99)

0.03

LPL(4), IL6(3), CEBPD(2)

[69-73]


Indomethacin

3 × 10-3

17 (99)

0.05

CCDC50(1), BIRC3(1), DNAJB(1)

[74]


Diethylstilbestrol

3 × 10-3

18 (99)

0.05

IL6(1), MARCKS(1), MXD1(1), MMP7(1)

[75,76]


Cyclophosphamide

4 × 10-4

19 (99)

0.06

IL6(3), MARCKS(1), PSMA5(1)

[77-79]


Bisphenol A

6 × 10-3

21 (99)

0.08

CEBPD(1), MLF1(1), DTL(1)

[80]


Shown in the table are a subset of the highly ranked chemicals (p < 0.01) that were predicted to have association with breast cancer gene expression (non-tumorigenic) and had evidence of association with the MeSH term "Breast Neoplasms". Columns have similar definitions as Table 2.

Patel and Butte BMC Medical Genomics 2010 3:17   doi:10.1186/1755-8794-3-17

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