Table 3

Prediction of environmental chemicals associated with lung cancer samples (GSE10072).

Chemical Predicted

Hypergeometric P-value

Rank (percentile)

q-value

Relevant genes in set (number of references)

Citations


Doxorubicin

1 × 10-6

16 (99)

4 × 10-4

CASP3(60), ABCB1(28), BAX(26), BCL2 (23)

[54]


Sodium arsenite

8 × 10-6

20 (98)

4 × 10-4

JUN(13), NQ01(6), EGR1(6)

[55-57]


Vanadium pentoxide

1 × 10-5

24 (98)

6 × 10-4

HBEGF(3), CDK7(1), CDKN1B (1), CDKN1C(1)

[58]


Dimethylnitrosamine

6 × 10-5

27 (98)

7 × 10-4

TGFB1(23), TIMP1(15), PCNA(6)

[31]


Indomethacin

2 × 10-4

34 (97)

0.002

BIRC5(3), CDKN1B(2), MMP9(2)

[59-61]


2-Acetylaminofluorene

3 × 10-4

36 (97)

0.003

ABCB1(4), ABCG2(4), KRT19(2)

[62]


Asbestos, Serpentine

4 × 10-4

39 (97)

0.004

IL6(2), MMP9(2), MMP12(2), PDGFB(2)

[63]


Shown in the table are a subset of the highly ranked chemicals (p < 0.001) that were predicted to have association with lung cancer gene expression (non-smokers) and had evidence of association with the MeSH term "Lung Neoplasms". Columns have similar definitions as Table 2.

Patel and Butte BMC Medical Genomics 2010 3:17   doi:10.1186/1755-8794-3-17

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