Table 2

Signaling Pathway Networks that Involve Human Pituitary Adenoma Differentially Expressed Proteins (DEPs).

Networks

Nodes (genes; proteins) in Network

Score

Nodes

Identified Nodes (DEPs)

Top Functions


7

AKR1B1, Akt, ATP5B, CAPZB, Caspase, CRYM, Cytochrome c, DBI, ERK, F10, FYN, GDI1, GH1, GLO1, GPX4, GSTM2, HSP90B1, HSPB1, HSPB8, Igfbp, IGFBP6, Insulin, Jnk, P38 MAPK, PDGF BB, PI3K, Pka, PLC, PPID, PPP2R2A, PRL, Ras, TGM2, VIM, YWHAQ (includes EG:10971)

53

35

22

Cancer, Endocrine System Development and Function, Organ Morphology

8

ACOT2, ACSL1, ADRB3, AKR1B1, ANGPTL4, COL6A2, COX2, COX6B1, Cytochrome c oxidase, DBI, DLK1, DNAJB6, EDN2, ERP29, F2, GCLC, IDH1, IL4R, L-triiodothyronine, LIPE, MMP19, MYCL1, MYLPF, MYOD1, OGN, PPARG, PRDX3, prostaglandin E2, RXRB, SERPINB8, SKI, SLC2A1, TAGLN3, TGFB1, TNF

22

35

11

Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry

9

ALB, APOA1, CALB1, CD59, CNTF, CXCR4, CYP2E1, DDIT3, EPO, FGG, G alpha, GH2, GNAO1, GNAS, GPNMB, GPSM1, HBA2, HBB (includes EG:3043), HBD, Histone h3, IFNG, IGFBP2, IGLC1, KLF3, KRT16, Mapk, NFkB, NUPR1, PIK3R1, PIM3, SCGN, SH2B1, SOCS3, TAC1, TPH2

19

35

10

Hematological System Development and Function, Tissue Morphology, Hematological Disease


Zhan and Desiderio BMC Medical Genomics 2010 3:13   doi:10.1186/1755-8794-3-13

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