Table 1

Signaling Pathway Networks that Involve Pituitary Adenoma Mapping Proteins.

Networks

Nodes (genes; proteins) in Network

Score

Nodes

Identified Nodes (Proteins)

Top Functions


1

AKR1B1, ANXA1, ANXA2, ANXA5, APCS, C3, CAT, Complement component 1, ECHS1, ENO1, ERK, F10, FGG, FTH1, FTL, FYN, GDI2, GH1, Glutathione transferase, GST, GSTM2, GSTO1, GSTP1, HADHB, Nfat, PCBP1 (includes EG:5093), PHB (includes EG:5245), PLC, PPIA, PRDX2, PRDX6, SERPINE1, Stat3-Stat3, T3-TR-RXR, UCHL1

58

35

27

Cancer, Cell-To-Cell Signaling and Interaction, Small Molecule-Biochemistry

2

ADCY, ATP5B, CALR, CAPNS1, CCNH, CRABP2, ERP29, FHL2, FKBP5, G-protein beta, GNAO1, GNB2, GNB3, HLA-A, HSF1, HSP, Hsp27, Hsp70, Hsp90, HSPA5, HSPA8, HSPB1, KRT19, MHC Class I, NFkB, NME2, P4HB, PAFAH1B2, PDIA3, Rbp, RBP1, SOD1, Tap, YWHAE, YWHAQ (includes EG:10971)

52

34

25

Post-Translational Modification, Protein Folding, Hematological Disease

3

14-3-3, Actin, Akt, ALB, APOA1, Calmodulin, Calpain, CBS, Dynamin, E2f, F Actin, GSN, HNRNPC, HPX, IMMT, Integrin, KRT9, LDL, MAP3K8, Mapk, NAPA, PI3K, PITPNA, Pkc(s), Pld, Proteasome, PSMC1, PSME1, PSME2, Ras, TF, Tgf beta, TPM3, TPM4, Tropomyosin

31

35

17

Organ Morphology, Reproductive System Development and Function, Molecular Transport

4

A1BG, ADSL, ARHGEF5, BLVRB, C22ORF28, C4ORF27, CREBL2, Cytochrome c, EIF6, ENO2, ERBB2, FGF7, FSH, HNF4A, IDH1, IDH3A, IL6, KLHDC3, LEP, MCCC1, MYL6, MYL9 (includes EG:10398), NDUFS3, NPNT, OFD1, PPARGC1A, RIOK1, SLC25A20, STK17A, SUCLA2, THSD1, TIMD2, TLN1, VAT1, YWHAB

22

35

13

Lipid Metabolism, Molecular Transport, Small-Molecule Biochemistry

5

ACTR3, AKR7A2, BMP3, Ck2, DUSP8, EBAG9, EEF1A1, ELP3, ERAF, Histone h3, HSD17B10, Insulin, Jnk, KITLG (includes EG:4254), KLK11, MAGED2, MAS1, MDH2, OVOL1, P38 MAPK, PDGF BB, PGLS, PPM1L, PRKRIR, RNA polymerase II, SF3B2, SLC25A11, SLC25A12, STARD10, STK4, TGFB1, UGDH, VAPB, WASF3, WDR1

18

36

11

Cell Death, Hematological Disease, Cellular Development

6

3-hydroxybutyric acid, ABCC9, AK1, ANXA4, AQP9, BPGM, CA14, CA1 (includes EG:759), CCT3, EEF1G, EIF4EBP2, FADS2, FBXO8, FH, GNPAT, HNF1A, ILF2 (includes EG:3608), INS1, KCNJ8, KCNJ11, L-triiodothyronine, LDHB, MGST3, MYC, PAX4, PGAM1, PRDX3, SCD2, SLC37A4, SRI, SRM, TPI1, UMPS, VDAC2, XRCC6

18

35

11

Lipid Metabolism, Small-Molecule Biochemistry, Carbohydrate Metabolism


Zhan and Desiderio BMC Medical Genomics 2010 3:13   doi:10.1186/1755-8794-3-13

Open Data