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Open Access Research article

Signaling pathway networks mined from human pituitary adenoma proteomics data

Xianquan Zhan123* and Dominic M Desiderio12345

Author Affiliations

1 Charles B. Stout Neuroscience Mass Spectrometry Laboratory, University of Tennessee Health Science Center, Memphis, Tennessee, USA

2 Department of Neurology, University of Tennessee Health Science Center, Memphis, Tennessee, USA

3 Clinical and Translational Science Institute, University of Tennessee Health Science Center, Memphis, Tennessee, USA

4 Department of Molecular Science, University of Tennessee Health Science Center, Memphis, Tennessee, USA

5 University of Tennessee Cancer Institute, University of Tennessee Health Science Center, Memphis, Tennessee, USA

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BMC Medical Genomics 2010, 3:13  doi:10.1186/1755-8794-3-13

Published: 28 April 2010

Additional files

Additional file 1:

Supplementary Tables. This file contains supplementary tables S1-S5. Supplementary Table S1 shows the protein-mapping data identified from a pituitary adenoma tissue with two-dimensional gel electrophoresis (2DGE) and mass spectrometry. Supplementary Table S2 shows comparative proteomic data identified from human pituitary adenoma tissues with 2DGE-based comparative proteomics. Supplementary Table S3 shows nitroproteins, and proteins that interact with nitroproteins, identified from a human pituitary adenoma tissue with nitrotyrosine affinity enrichment and tandem mass spectrometry. Supplementary Table S4 shows nitroproteins identified from human pituitary post-mortem control tissue with 2DGE-based nitrotyrosine Western Blot and tandem mass spectrometry. Supplementary Table S5 shows clinical and pathological characteristics of pituitary adenomas and controls used in comparative proteomics study.

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Additional file 2:

Supplementary Figures. This file contains supplementary figures S1-S4. Supplementary Figure S1 shows significant canonical pathways that are involved in human pituitary adenoma mapping proteomic data. Supplementary Figure S2 shows significant canonical pathways that are involved in human pituitary adenoma comparative proteomic data. Supplementary Figure S3 shows significant canonical pathways that are involved in human pituitary adenoma nitroproteomics data. Supplementary Figure S4 shows significant canonical pathways that are involved in human pituitary control nitroproteomics data.

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