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Open Access Highly Accessed Research article

Systematic analysis, comparison, and integration of disease based human genetic association data and mouse genetic phenotypic information

Yonqing Zhang1, Supriyo De1, John R Garner1, Kirstin Smith1, S Alex Wang2 and Kevin G Becker1*

Author Affiliations

1 Gene Expression and Genomics Unit, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 USA

2 Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892 USA

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BMC Medical Genomics 2010, 3:1  doi:10.1186/1755-8794-3-1

Published: 21 January 2010

Additional files

Additional file 1:

Hierarchical clustering of 480 Human GAD disease gene sets. This file contains a display of hierarchical clustering of 480 Human GAD disease gene sets, each gene set contain at least 3 genes each.

Format: PDF Size: 816KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 2:

Individual human disease functional clusters. This file contains selected subsets of Additional File 1 including; a. tumorigenesis, b. autoimmune, c. cardiovascular, d. metabolism, and e. behavior.

Format: PDF Size: 419KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 3:

Hierarchical clustering of 2067 Mouse phenotypic gene sets. This file contains a display of hierarchical clustering of 2067 Mouse phenotypic gene sets, each gene set contain at least 10 genes each.

Format: PDF Size: 2.7MB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 4:

Individual mouse phenotypic functional clusters. This file contains selected subsets of Additional File 2 including; a. immune function, b. metabolism, c. neurological function/behavior, d. DNA replication/tumorigenesis, e. development and f. cardiovascular.

Format: PDF Size: 469KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data