Table 2

Top 59 genes differentially expressed in sinonasal adenocarcinomas after two-class comparison analysis

Accession

Number

Gene Symbol

Gene annotation

Fold change (log2)


NM_006149

LGALS4

Up-regulated genes

lectin, galactoside-binding, soluble, 4 (galectin 4)

3.084

NM_016234

ACS5

fatty-acid-Coenzyme A ligase, long-chain 5

2.621

NM_001845

COL4A1

collagen, type IV, alpha 1

1.779

NM_002228

JUN

v-jun sarcoma virus 17 oncogene homolog (avian)

1.758

NM_001816

CEACAM8

carcinoembryonic antigen-related cell adhesion molecule 8

1.732

NM_001122

ADFP

adipose differentiation-related protein

1.628

XM_067746

similar to 60 kDa heat shock protein, mitochondrialprecursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein60) (HSP-60)

1.617

NM_004591

CCL20

chemokine (C-C motif) ligand 20

1.560

BC000097

TGFBI

transforming growth factor, beta-induced, 68 kDa

1.493

NM_000393

COL5A2

collagen, type V, alpha 2

1.461

NM_003130

SRI

sorcin

1.456

NM_001153

ANXA4

annexin A4

1.434

NM_005566

LDHA

lactate dehydrogenase A

1.416

NM_005563

STMN1

stathmin 1/oncoprotein 18

1.414

NM_017958

PLEKHB2

pleckstrin homology domain containing, family B (evectins) member 2

1.409

XM_092196

similar to Cytochrome c, somatic (LOC164837), mRNA.

1.387

AF112214

MRPL13

mitochondrial ribosomal protein L13

1.370

AJ250915

HSPD1

heat shock 60 kDa protein 1 (chaperonin)

1.346

BC003623

YWHAZ

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide

1.342

NM_006111

ACAA2

acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)

1.335

NM_021821

MRPS35

mitochondrial ribosomal protein S35

1.329

NM_002592

PCNA

proliferating cell nuclear antigen

1.319

NM_001827

CKS2

CDC28 protein kinase regulatory subunit 2

1.278

AB062125

TPM3

tropomyosin 3

1.224

NM_016245

DHRS8

dehydrogenase/reductase (SDR family) member 8

1.206

NM_001226

CASP6

caspase 6, apoptosis-related cysteine protease

1.194

NM_004670

PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

1.172

XM_088293

similar to cytochrome c (LOC157317), mRNA.

1.164

NM_001428

ENO1

enolase 1, (alpha)

1.145

XM_060849

similar to cytochrome C, expressed in somatic tissues(LOC128146), mRNA.

1.133

AF135381

CKLF

chemokine-like factor

1.133

X84907

ENO1

enolase 1, (alpha)

1.121

NM_005720

ARPC1B

actin related protein 2/3 complex, subunit 1B, 41 kDa

1.114

NM_021130

PPIA

peptidylprolyl isomerase A (cyclophilin A)

1.110

NM_001288

CLIC1

chloride intracellular channel 1

1.095

BC015130

CYCS

cytochrome c, somatic

1.081

NM_012255

XRN2

5'-3' exoribonuclease 2

1.068

M34664

HSPD1

heat shock 60 kDa protein 1 (chaperonin)

1.066

AF054185

PSMA7

proteasome (prosome, macropain) subunit, alpha type, 7

1.044

NM_006601

TEBP

unactive progesterone receptor, 23 kD

1.037

AF136630

CBX3

chromobox homolog 3 (HP1 gamma homolog, Drosophila)

1.023

AF274941

CKS1B

CDC28 protein kinase regulatory subunit 1B

1.013

AF320053

MYCN

v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)

1.006

Down-regulated genes

NM_001831

CLU

clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)

-3.606

NM_005978

S100A2

S100 calcium binding protein A2

-2.152

S68290

AKR1C1

aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)

-2.102

NM_003713

PPAP2B

phosphatidic acid phosphatase type 2B

-1.966

AB000889

PPAP2B

phosphatidic acid phosphatase type 2B

-1.936

NM_001321

CSRP2

cysteine and glycine-rich protein 2

-1.916

NM_006485/

FBLN1

fibulin 1

-1.799

AF007162

CRYAB

crystallin, alpha B

-1.590

NM_002825

PTN

pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)

-1.405

NM_001063

TF

transferrin

-1.256

NM_004186

SEMA3F

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F

-1.246

NM_000424

KRT5

keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)

-1.207

AF059617

PLK2

polo-like kinase 2 (Drosophila)

-1.186

NM_005596

NFIB

nuclear factor I/B

-1.149

NM_006206

PDGFRA

platelet-derived growth factor receptor, alpha polypeptide

-1.090

NM_005900

MADH1

MAD, mothers against decapentaplegic homolog 1 (Drosophila)

-1.047


Tripodi et al. BMC Medical Genomics 2009 2:65   doi:10.1186/1755-8794-2-65

Open Data