IPA analysis of genes with Diagnosis × Glucose deprivation × Probeset effects identified a network of 18 genes. Red indicates genes upregulated in schizophrenia in the glucose-deprived condition, green indicates genes down-regulated in schizophrenia in the glucose deprived condition, compared to normal controls in the glucose normal condition. White indicates the genes were not part of the dataset file genes. Solid lines indicate direct interactions, while dashed lines indicate indirect interactions. The network shapes are indicative of the molecular class (oval -- transcription regulator; square -- cytokine, trapezoid -- transporter; diamond -- enzyme; double circle -- complex/group; circle -- other). The network included 18 genes that showed diagnosis-dependent expression alterations following glucose deprivation, with Hepatocyte nuclear factor 4, alpha (HNF4A) as one node in this gene network.
Martin et al. BMC Medical Genomics 2009 2:62 doi:10.1186/1755-8794-2-62