Figure 1.

Muscle plasticity GO node. As an example, the process 'muscle plasticity' is shown before (Panel A) and after (Panel B) our modifications. Previously, the process of muscle plasticity had no specific child terms, therefore all annotations of the gene products involved in subprocesses of muscle adaptation had to be made directly to the muscle plasticity term. As part of our work we renamed muscle plasticity to muscle adaptation (highlighted in red) in keeping with the existing term definition, and added new terms for various sub-processes of muscle adaptation such as muscle atrophy, hypertrophy and hyperplasia. As a result of this work the gene products previously annotated directly to muscle plasticity can now be annotated to the more specific process terms giving far better reasoning power for analysis of high-throughput experiments. GO terms are in blue ovals, and annotated gene products are in green rectangles. Black lines marked 'is_a' indicate the is_a relationship. Black lines marked 'regulates' indicate the regulates relationship. Red lines indicate annotation of a gene product to a GO process term. Annotation of a gene product to a GO process term indicates that the gene product participates in the process represented by the GO term.