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Open Access Research article

Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells

Alissar Nehmé1, Edward K Lobenhofer24, W Daniel Stamer3 and Jeffrey L Edelman1*

Author Affiliations

1 Department of Biological Sciences, Allergan, Inc., Irvine, CA 92612, USA

2 Cogenics™, A Division of Clinical Data®, Morrisville, NC 27560, USA

3 Department of Ophthalmology and Vision Science, University of Arizona, Tucson, AZ 85724, USA

4 Current address : Amgen, Inc., Thousand Oaks, CA 93120, USA

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BMC Medical Genomics 2009, 2:58  doi:10.1186/1755-8794-2-58

Published: 10 September 2009

Additional files

Additional file 1:

Comparison of lists of differentially expressed genes in response to DEX, FA, and TA in TM 86 and TM 93. These lists show, for TM 86 and TM 93, the genes that were differentially regulated in response to a single treatment (DEX, FA, or TA), as well as the genes commonly expressed across multiple treatments.

Format: XLS Size: 3.4MB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 2:

The "change" list of enriched gene ontological processes in response to DEX in TM 86. A list of biological processes (and associated statistical enrichment values) representing the entire list of transcripts and negating the directionality of the change. The list was sorted by p-value.

Format: XLS Size: 1.1MB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 3:

The "change" list of enriched gene ontological processes in response to FA in TM 86. A list of biological processes (and associated statistical enrichment values) representing the entire list of transcripts and negating the directionality of the change. The list was sorted by p-value.

Format: XLS Size: 1.6MB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 4:

The "change" list of enriched gene ontological processes in response to TA in TM 86. A list of biological processes (and associated statistical enrichment values) representing the entire list of transcripts and negating the directionality of the change. The list was sorted by p-value.

Format: XLS Size: 1.6MB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 5:

The "change" list of enriched gene ontological processes in response to DEX, FA and TA in TM 86. A list of biological processes (and associated statistical enrichment values) representing the entire list of transcripts and negating the directionality of the change. The list was sorted by p-value.

Format: XLS Size: 1MB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 6:

The "change" list of enriched gene ontological processes in response to DEX in TM 93. A list of biological processes (and associated statistical enrichment values) representing the entire list of transcripts and negating the directionality of the change. The list was sorted by p-value.

Format: XLS Size: 1.1MB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 7:

The "change" list of enriched gene ontological processes in response to FA in TM 93. A list of biological processes (and associated statistical enrichment values) representing the entire list of transcripts and negating the directionality of the change. The list was sorted by p-value.

Format: XLS Size: 1.6MB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 8:

The "change" list of enriched gene ontological processes in response to TA in TM 93. A list of biological processes (and associated statistical enrichment values) representing the entire list of transcripts and negating the directionality of the change. The list was sorted by p-value.

Format: XLS Size: 1.6MB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 9:

The "change" list of enriched gene ontological processes in response to DEX, FA and TA in TM 93. A list of biological processes (and associated statistical enrichment values) representing the entire list of transcripts and negating the directionality of the change. The list was sorted by p-value.

Format: XLS Size: 1MB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data