Table 1

List of most differentially regulated genes in 4OHT-treated K13 ER-HUVECs.

Gene Name

Gene

Entrez Gene

Fold Change


Up-regulated genes


1

chemokine (C-C motif) ligand 2

CCL2

6347

71.4

2

ubiquitin D

UBD

10537

58.4

3

chemokine (C-C motif) ligand 20

CCL20

6364

53.1

4

chemokine (C-C motif) ligand 5

CCL5

6352

48.3

5

chemokine (C-X-C motif) ligand 10

CXCL10

3627

47.7

6

vascular cell adhesion molecule 1

VCAM1

7412

46.0

7

selectin E (endothelial adhesion molecule 1)

SELE

6401

35.4

8

superoxide dismutase 2, mitochondrial

SOD2

6648

35.2

9

chemokine (C-X-C motif) ligand 3

CXCL3

2921

33.8

10

chemokine (C-X-C motif) ligand 2

CXCL2

2920

32.2

11

interleukin 8

IL8

3576

31.5

12

chromosome 15 open reading frame 48

C15orf48

84419

29.6

13

solute carrier family 7 (cationic amino acid transporter)

SLC7A2

6542

23.2

14

chemokine (C-X3-C motif) ligand 1

CX3CL1

6376

22.3

15

intercellular adhesion molecule 1 (CD54)

ICAM1

3383

22.2

16

tumor necrosis factor, alpha-induced protein 6

TNFAIP6

7130

21.2

17

interleukin 6 (interferon, beta 2)

IL6

3569

21.1

18

colony stimulating factor 2 (granulocyte-macrophage)

CSF2

1437

15.1

19

interferon stimulated exonuclease gene 20 kDa

ISG20

3669

13.6

20

chemokine (C-X-C motif) ligand 5

CXCL5

6374

13.0

21

laminin, gamma 2

LAMC2

3918

12.7

22

tumor necrosis factor, alpha-induced protein 3

TNFAIP3

7128

12.5

23

matrix metallopeptidase 10 (stromelysin 2)

MMP10

4319

11.5

24

tumor necrosis factor, alpha-induced protein 2

TNFAIP2

7127

11.3

25

Epstein-Barr virus induced gene 3

EBI3

10148

9.8

26

tumor necrosis factor (ligand) superfamily, member 13b

TNFSF13B

10673

9.6

27

phospholipase A1 member A

PLA1A

51365

9.4

28

GTP cyclohydrolase 1 (dopa-responsive dystonia)

GCH1

2643

9.0

29

nuclear factor of kappa light polypeptide gene enhancer, alpha

NFKBIA

4792

8.3

30

proteasome (prosome, macropain) subunit, beta type, 9

PSMB9

5698

7.9

31

Chemokine (C-X-C motif) 1

CXCl1

2919

7.7

32

histone cluster 2, H2aa3

HIST2

723790

7.5

33

HLA-G histocompatibility antigen, class I, G

HLA-G

3135

7.2

34

hydroxysteroid (11-beta) dehydrogenase 1

HSD11B1

3290

7.2

35

chemokine (C-X-C motif) receptor 7

CXCR7

57007

7.0

36

major histocompatibility complex, class I, B

HLA-B

3106

6.3

37

nuclear receptor coactivator 7

NCOA7

135112

6.1

38

myxovirus (influenza virus) resistance 2 (mouse)

MX2

4600

5.8

39

radical S-adenosyl methionine domain containing 2

RSAD2

91543

5.6

40

TNFAIP3 interacting protein 1

TNIP1

10318

5.5

41

tissue factor pathway inhibitor 2

TFPI2

7980

5.4

42

interleukin 32

IL32

9235

5.3

43

Nibrin

NBN

4683

5.2

44

receptor (chemosensory) transporter protein 4

RTP4

64108

5.2

45

baculoviral IAP repeat-containing 3

BIRC3

330

5.1

46

interleukin 7 receptor /// interleukin 7 receptor

IL7R

3575

5.0

47

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

TAP1

6890

5.0

48

papilin, proteoglycan-like sulfated glycoprotein

PAPLN

89932

4.9

49

Major histocompatibility complex, class I, F

HLA-F

3134

4.9

50

myosin, light chain kinase

MYLK

4638

4.9


Down-regulated genes


1

extracellular link domain containing 1

XLKD1

10894

11.1

2

chemokine (C-C motif) ligand 14

CCL14

6358

11.0

3

ADAM metallopeptidase with thrombospondin type 1 motif, 18

ADAMTS18

170692

7.8

4

LIM domain binding 2

LDB2

9079

6.7

5

keratin 18

KRT18

3875

5.3

6

dual specificity phosphatase 4

DUSP4

1846

5.3

7

ribonuclease, RNase A family, 1 (pancreatic)

RNASE1

6035

4.7

8

periostin, osteoblast specific factor

POSTN

10631

4.7

9

insulin-like growth factor binding protein 5

IGFBP5

3488

4.6

10

regulator of G-protein signalling 5

RGS5

8490

4.6

11

uroplakin 1B /// regulator of G-protein signalling 5

UPK1B

7348

4.5

12

regulator of G-protein signalling 4

RGS4

5999

5.5

13

Palmdelphin

PALMD

54873

3.8

14

latent transforming growth factor beta binding protein 2

LTBP2

4053

3.2

15

C-X-C chemokine receptor type 4

CXCR4

7852

3.1


Punj et al. BMC Medical Genomics 2009 2:50   doi:10.1186/1755-8794-2-50

Open Data