Responder Classifications. A graphical representation of the three phenotype classification methods: Standard Datenum (SD), Incremental Reduction (IR) and Bimodal classification (BM). Figure 1A: SD, A histogram showing the log10 change in viral load of all patients in the database. Patients labelled as "responders" are marked in pink and non-responders in "blue". Figure 1B: IR, Three scatter plots representing the viral load vs. CD4 counts for all patients in the database after 8, 12, and 24 weeks of therapy. Patients which decreased in viral load in 75% of their visits are labelled as "responders" and marked in pink; those that did not are labelled as "non-responders" and marked in blue. Figure 1C: BM, A histogram of the change in viral load after 24 weeks of therapy. Those patients that decreased by more than 2000 copies/ml were labelled as "responders" and are marked in pink; those that did not were labelled as "non-responders" and are marked in blue.
Dampier et al. BMC Medical Genomics 2009 2:47 doi:10.1186/1755-8794-2-47