Table 2

Three altered bio-systems in CFS

Oxidative Stress Genes


Up-regulated

Prostaglandin Synthase: COX-1 and 2, haemoglobin gamma A and gamma G

Down-regulated

Glutathion-s-transferase


Apoptosis Genes: Up-regulated


Annexin -A3, -A5, Serine/threonine kinase 17b, Histones 1&2, Protein S (alpha), Serum deprivation response (Phosphatidylserine binding protein)

Caspase 1, TGFβ1

Death effector filament forming CED4-like apoptosis protein, Complement 3a receptor 1, Early growth response 1, TNF-A1P3, -RSF17, -SF4


Immune Dysfunction Genes (including markers of viral immuno-modulation/evasion)


Up-regulated

DAF (CD55) & CD46

Antigen processing via MHC class II (MHC II DP α1 and DR α)

IL-12, IL-13 & IL-6 biosynthesis

Down-regulated: The MHC-1 system including:

Natural Killer cell receptors (KIR)

TCR complex (T-cell receptors α, β, δ, γ)

NO production (up-regulation of arginase I & II)

Flavohaemoprotein B5

Leukocyte-derived arginine aminopeptidase (L-rap)


Gow et al. BMC Medical Genomics 2009 2:38   doi:10.1186/1755-8794-2-38

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