Table 2

Biological pathways repressed by hypermethylation

Pathways

Downregulated genes

(1286)

Hypermethylated and downregulated genes

(55)

Fisher's Exact Test p-values§



Input genes in pathway

Corrected p-value

Input genes in pathway

Genes in pathway

Corrected p-value


Cell adhesion molecules

14

1.95E-164

4

ITFAV, CLDN11, NEO1, CDH2

0

0.002*

Tight junction

13

1.40E-03

3

CLDN11, PPP2R4, INADL

9.93E-07

0.016*

PPAR signaling pathway

6

1.17E-01

2

CPT1A, SLC27A6

5.20E-03

0.024*

Leukocyte transendothelial migratio'n

9

2.34E-01

1

CLDN11

2.51E-02

0.326


Pathways listed are all pathways regulated by hypermethylated and downregulated genes, determined by Pathway Express corrected p-value < 0.05.

§ Pathway enrichment p-values were calculated using a one-tail Fisher's exact test. Asterisks show p-value < 0.05

Li et al. BMC Medical Genomics 2009 2:34   doi:10.1186/1755-8794-2-34

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