Detailed transcriptome atlas of the pancreatic beta cell

doi:10.1186/1755-8794-2-3

BMC Medical Genomics

Volume 2

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Kutlu B
Burdick D
Baxter D
Rasschaert J
Flamez D
Eizirik DL
Welsh N
Goodman N
Hood L

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Burdick D
Baxter D
Rasschaert J
Flamez D
Eizirik DL
Welsh N
Goodman N
Hood L
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Research article

Detailed transcriptome atlas of the pancreatic beta cell

Burak Kutlu¹ , David Burdick¹ , David Baxter¹ , Joanne Rasschaert² , Daisy Flamez² , Decio L Eizirik² , Nils Welsh³ , Nathan Goodman¹ and Leroy Hood¹

¹Institute for Systems Biology, Seattle, WA, USA

²Laboratory of Experimental Medicine, Universite Libre de Bruxelles, Brussels, Belgium

³Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

author email corresponding author email

BMC Medical Genomics 2009, 2:3doi:10.1186/1755-8794-2-3


Published:	15 January 2009

Additional files

Additional file 1:

Supplementary methods. Supplementary information about Methods and additional findings.

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Additional file 2:

MPSS gene expression data. Tpm values for each gene in MPSS data.

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Additional file 3:

GO term enrichment analysis of MPSS data. GO term enrichment analysis of 1: top 200 genes, 2: genes expressed lower than 25 transcripts per million (tpm) in the human islet MPSS data

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Additional file 4:

Transcription factor analysis. Analysis of transcription factors in rat INS cell data based on domain classification.

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Additional file 5:

INS-1 cell microarray data analysis results. This file contains 1. MAS5-normalized expression data of rat β, α and INS cell. 2. Differential expression analysis of genes expressed in β vs α cells. 3. Differential expression analysis of genes expressed in β vs INS cells.

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Additional file 6:

GO term enrichment analysis of INS cell data. GO term enrichment analysis genes expressed in β, α and INS cells.

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Additional file 7:

Pancreatic islet-specific genes. Genes that are enriched in pancreatic islets compared to other tissues in the body.

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Additional file 8:

The overlap of these pancreatic islet-specific genes with β and α cell enriched genes. The intersection of genes in Additional File 7 with either genes expressed strongly in either β or α cells.

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