BMC Medical Genomics

official impact factor 3.77

Open Access Technical advance

Identification of microbial DNA in human cancer

Christopher G Duncan1, Rebecca J Leary2, Jimmy CH Lin2, Jordan Cummins2, Chunhui Di1, Carl F Schaefer3, Tian-Li Wang2, Gregory J Riggins4, Jennifer Edwards4, Darell Bigner1, Levy Kopelovich5, Bert Vogelstein2, Kenneth W Kinzler2, Victor E Velculescu2 and Hai Yan1*

Author Affiliations

1 Preston Robert Tisch Brain Tumor Center, Pediatric Brain Tumor Foundation Institute, Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA

2 The Ludwig Center for Cancer Genetics and Therapeutics and The Howard Hughes Medical Institute, The Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland 21231, USA

3 Center for Biomedical Informatics and Information Technology, National Cancer Institute, Rockville, Maryland 20852, USA

4 Department of Neurosurgery, Johns Hopkins University Medical School, Baltimore, MD 21231, USA

5 Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20892-7322, USA

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BMC Medical Genomics 2009, 2:22 doi:10.1186/1755-8794-2-22

Published: 8 May 2009

Additional files

Additional file 1:

Table S1.1, Bacterial and Viral Virtual Tag Library. Library contains 21 bp NlaIII tags closest to SacI sites from indicated bacterial or viral databases (bacterial genomes obtained from http://ftpgib.genes.nig.ac.jp webcite; viral genomes obtained from ftp://ftp.ncbi.nih.gov/refseq/release/viral/ webcite) which are not present in the human genome sequence (Build 36, March 24 2008). File 1 of 3.

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Additional file 2:

Table S1.2, Bacterial and Viral Virtual Tag Library. Library contains 21 bp NlaIII tags closest to SacI sites from indicated bacterial or viral databases (bacterial genomes obtained from http://ftpgib.genes.nig.ac.jp webcite; viral genomes obtained from ftp://ftp.ncbi.nih.gov/refseq/release/viral/) which are not present in the human genome sequence (Build 36, March 24 2008). File 2 of 3.

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Additional file 3:

Table S1.3, Bacterial and Viral Virtual Tag Library. Library contains 21 bp NlaIII tags closest to SacI sites from indicated bacterial or viral databases (bacterial genomes obtained from http://ftpgib.genes.nig.ac.jp webcite; viral genomes obtained from ftp://ftp.ncbi.nih.gov/refseq/release/viral/) which are not present in the human genome sequence (Build 36, March 24 2008). File 3 of 3.

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Additional file 4:

Table S2, Identification of microbial DNA sequences using DK-MICROBE. Table of microbial DNA tag sequences observed in the DK-MICROBE human cancer screening.

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