  Research articleThe apoptotic machinery as a biological complex system: analysis of its omics and evolution, identification of candidate genes for fourteen major types of cancer, and experimental validation in CML and neuroblastomaCinzia Di Pietro* 1 1Dipartimento di Scienze BioMediche, Sezione di Biologia Generale, Biologia Cellulare, Genetica Molecolare G Sichel, Unità di Biologia Genomica e dei Sistemi Complessi, Genetica, Bioinformatica, Università di Catania, 95123 Catania, Italy 2Dipartimento di Scienze BioMediche, Sezione di Ematologia, Università di Catania, 95125 Catania, Italy 3Dipartimento di Scienze Ginecologiche e Microbiologiche, Università di Catania, 95125 Catania, Italy 4Dipartimento di Scienze Chirurgiche, Università di Catania, 95125 Catania, Italy 5Dipartimento di Anatomia, Patologia Diagnostica, Medicina Legale, Igiene e Sanità Pubblica, Università di Catania, 95125 Catania, Italy 6Courant Institute of Mathematical Sciences, New York University, New York, NY 10012, USA
BMC Medical Genomics 2009, 2:20doi:10.1186/1755-8794-2-20
Additional filesAdditional file 1: Gene symbol, name and localization of AM protein-coding genes and AM MIR-coding genes Format: XLS Size: 82KB Download file This file can be viewed with: Microsoft Excel Viewer Additional file 2: GO classification of AM genes. Panel A. General Function of AM protein – encoding genes. Panel B. Biological Processes. Panel C. Molecular Functions. Panel D. Subcellular Localization. Panel E. General Function of AM genes targets of MIRs. Format: TIFF Size: 541KB Download file Additional file 3: Experimentally verified MIRs targeting AM genes. Format: DOC Size: 34KB Download file This file can be viewed with: Microsoft Word Viewer Additional file 4: MIR host genes in AM. Format: DOC Size: 25KB Download file This file can be viewed with: Microsoft Word Viewer Additional file 5: AM genomics. Panel A. Genome Map of AM Genes. Panel B. Comparison of the genome distribution of AM genes with respect to the other human genes. Format: TIFF Size: 340KB Download file Additional file 6: Genome clusters of AM genes in human, chimpanzee, mouse. Format: DOC Size: 53KB Download file This file can be viewed with: Microsoft Word Viewer Additional file 7: Proteomic features of AM. Panel A. Molecular weight distribution of 548 AM proteins. Panel B. Percentage of post-translational modifications of AM proteins. Panel C. Percentage of metal ions within the tertiary structure of AM proteins. Format: TIFF Size: 452KB Download file Additional file 8: Distribution of protein motifs and domains in AM. Format: TIFF Size: 403KB Download file Additional file 9: AM genes positional candidates in cancers (data from array-CGH). Format: XLS Size: 31KB Download file This file can be viewed with: Microsoft Excel Viewer Additional file 10: AM transcriptome data. Format: XLS Size: 57KB Download file This file can be viewed with: Microsoft Excel Viewer Additional file 11: AM genes localized in loss- or gain-regions and down or up regulated, respectively. Format: XLS Size: 20KB Download file This file can be viewed with: Microsoft Excel Viewer Additional file 12: Features of AM hubs. Format: DOC Size: 61KB Download file This file can be viewed with: Microsoft Word Viewer |
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