Complex nature of SNP genotype effects on gene expression in primary human leucocytes

Graham A Heap¹ , Gosia Trynka^2,3* , Ritsert C Jansen^2,4* , Marcel Bruinenberg² , Morris A Swertz² , Lotte C Dinesen⁵ , Karen A Hunt¹ , Cisca Wijmenga^2,3 , David A vanHeel¹ and Lude Franke^1,2,3

¹  Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, London, E1 2AT, UK

²  Genetics Department, University Medical Centre Groningen, University of Groningen, 9700 RB Groningen, the Netherlands

³  Complex Genetics Section, DBG-Department of Medical Genetics, University Medical Centre Utrecht, 3584 CG Utrecht, the Netherlands

⁴  Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, NL-9751 NN Haren, the Netherlands

⁵  Gastroenterology Unit, University of Oxford, Oxford OX3 7BN, UK