Table 1

Midkine expression is increased in the late stage prostate cancers. Normal and prostate cancer tissue microarray slides were immunohistochemically stained for midkine, using rabbit anti-midkine antibodies and ABC elite kit with DAB substrate, and counterstained by hematoxylin. The grading was assigned to each tissue core by a consensus review of two pathologists.

Tissue

No.

Gleason score

P

Midkine stain

P

median (range)

-

+

++


Normal

18

17

1

0

§

Early stage cancer

40

6 (5 – 7)

*

37

3

0

Late stage cancer

71

9 (8–10)

41

24

6


"-" indicates ≤ 20% of epithelial cells were immunopositive;

"+" indicates 20–50% of epithelial cells were immunopositive;

"++" indicates ≥ 50% of epithelial cells were immunopositive.

* P < 0.001, Gleason scores, early stage cancer v.s. late stage cancer.

§ P > 0.05, normal v.s. early stage cancer.

† P < 0.001, early stage cancer v.s. late stage cancer.

‡ P < 0.001, normal v.s. late stage cancer.

You et al. BMC Medical Genomics 2008 1:6   doi:10.1186/1755-8794-1-6

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