Research article
Gene expression in BMPR2 mutation carriers with and without evidence of Pulmonary Arterial Hypertension suggests pathways relevant to disease penetrance
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* Corresponding author: James West j.west@vanderbilt.edu
1 Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
2 Department of Genetics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
3 Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
4 Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
BMC Medical Genomics 2008, 1:45 doi:10.1186/1755-8794-1-45
Published: 29 September 2008Additional files
Additional file 1:
Genes Differentially Regulated in Affected vs Unaffected BMPR2 Mutation Carriers. Table, sorted by gene ontology group, of genes differentially regulated between affected and unaffected BMPR2 mutation carriers, including fold changes, absolute values, and associated GO consortium terms.
Format: XLS Size: 54KB Download file
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Additional file 2:
GTP-related probes differentially regulated in at least two patients compared to controls. Table, sorted by gene symbol, of Affymetrix probes differentially regulated in at least two affected BMPR2 mutation carriers compared to unaffected. Values that are differentially expressed at least 1.4× with a minimum 150 absolute change are highlighted in yellow; between 2 and 4 of the affected values for each probe will thus be altered.
Format: XLS Size: 30KB Download file
This file can be viewed with: Microsoft Excel Viewer