Tiling resolution array CGH and high density expression profiling of urothelial carcinomas delineate genomic amplicons and candidate target genes specific for advanced tumors

doi:10.1186/1755-8794-1-3

BMC Medical Genomics

Volume 1

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Heidenblad M
Lindgren D
Jonson T
Liedberg F
Veerla S
Chebil G
Gudjonsson S
Borg Å
Månsson W
Höglund M

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Heidenblad M
Lindgren D
Jonson T
Liedberg F
Veerla S
Chebil G
Gudjonsson S
Borg Å
Månsson W
Höglund M
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Research article

Tiling resolution array CGH and high density expression profiling of urothelial carcinomas delineate genomic amplicons and candidate target genes specific for advanced tumors

Markus Heidenblad¹ , David Lindgren¹ , Tord Jonson¹ , Fredrik Liedberg² , Srinivas Veerla¹ , Gunilla Chebil³ , Sigurdur Gudjonsson² , Åke Borg⁴ , Wiking Månsson² and Mattias Höglund¹

¹Department of Clinical Genetics, Lund University Hospital, SE-221 85 Lund, Sweden

²Department of Urology, Lund University Hospital, SE-221 85 Lund, Sweden

³Department of Pathology and Cytology, Helsingborg Hospital AB, SE-251 87 Helsingborg, Sweden

⁴Department of Oncology, Lund University Hospital, SE-221 85 Lund, Sweden

author email corresponding author email

BMC Medical Genomics 2008, 1:3doi:10.1186/1755-8794-1-3


Published:	31 January 2008

Additional files

Additional file 1:

Clinical data. Data on sex, age, stage, and grade given for each patient as well as which samples were analyzed by expression profiling.

Format: TIFF Size: 16.6MB Download file

Additional file 2:

Array-CGH data. BAC clone, genes, cytoband, start and end of BAC clone are given as well as the gene copy ratios in the individual samples.

Format: DOC Size: 56KB Download file

This file can be viewed with: Microsoft Word Viewer

Additional file 3:

Correlations between gene copy numbers and gene expression. The correlation between gene copy numbers and gene expression for genes within the 2p25, 6p22, and 8q22 amplicons.

Format: TXT Size: 13MB Download file

Additional file 4:

ID4, E2F3, and CDKLA1 gene expression. Results from Q-PCR analyses of ID4, E2F3, and CDKLA1 gene expression.

Format: XLS Size: 26KB Download file

This file can be viewed with: Microsoft Excel Viewer

Additional file 5:

Homozygous deletions. Table of cytogenetic and Mbp positions, sizes, and included genes in the identified homozygous deletions.

Format: DOC Size: 46KB Download file

This file can be viewed with: Microsoft Word Viewer