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This article is part of the supplement: Beyond the Genome 2012

Open Access Oral presentation

Analyzing genomes: is there a duty to disclose?

Amy McGuire

  • Correspondence: Amy McGuire

Author Affiliations

Baylor College of Medicine, Houston, TX, USA

BMC Proceedings 2012, 6(Suppl 6):O14  doi:10.1186/1753-6561-6-S6-O14

The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1753-6561/6/S6/O14


Published:1 October 2012

© 2012 McGuire; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Oral presentation

The potential to discover unanticipated clinically significant genetic variants during the course of research has stimulated much debate about the obligations of researchers to communicate such findings to study participants. Published guidelines suggest that researchers have an obligation to communicate valid and significant results, especially if they are clinically actionable. I will present data on the practices and perspectives of investigators conducting genome-wide association studies (GWAS) and will caution against the establishment of a general obligation to return results in research. I will compare the role-specific responsibilities of researchers with those of clinicians and discuss emerging standards for genomic analysis and communication of test results in the clinical setting.