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This article is part of the supplement: Metabolism, diet and disease

Open Access Oral presentation

Regulation of nutrient metabolism by nuclear receptor/FGF signaling pathways

Steven A Kliewer and David J Mangelsdorf*

  • * Corresponding author: David J Mangelsdorf

Author Affiliations

Department of Pharmacology and the Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA

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BMC Proceedings 2012, 6(Suppl 3):O16  doi:10.1186/1753-6561-6-S3-O16


The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1753-6561/6/S3/O16


Published:1 June 2012

© 2012 Kliewer and Mangelsdorf; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Oral presentation

The regulation of metabolism in fed and fasted states is governed by hormonal and nutrient-derived signals that are mediated in part by nuclear receptors. Just as insulin and glucagon help the body store and mobilize energy through their membrane receptors, nutrient-derived lipids activate their cognate nuclear receptors (e.g., FXR and PPARs) to govern transcriptional programs involved in energy storage and utilization during times of nutrient excess and privation. Recent work has revealed that many of the actions of these nuclear receptors are mediated by two atypical fibroblast growth factors (FGF19 and FGF21) that function as endocrine-like hormones. The characterization of these pathways in normal and metabolic disease animal models has led to an understanding of their physiologic and pharmacologic mechanism of action.