Table 1

Significant PharmGKB signaling pathways

PharmGKB ID

Pathway name

Permutation

p-value (weighted approach)

Permutation

p-value (unweighted approach)


PA164713582†*

Actions of nitric oxide in the heart

6.0 × 10–6

<1.0 × 10–6

PA164713652†*

VEGF hypoxia and angiogenesis

<1.0 × 10–6

6.0 × 10–6

PA164728105†*

Signaling events mediated by VEGFR1 and VEGFR2

<1.0 × 10–6

<1.0 × 10–6

PA164728138†*

S1P3 pathway

<1.0 × 10–6

<1.0 × 10–6

PA164713890†

Neurophilin interactions with VEGF and VEGFR

<1.0 × 10–6

1.7 × 10–5

PA164714260†

VEGF binds to VEGFR leading to receptor dimerization

<1.0 × 10–6

3.3 × 10–5

PA164728144†

VEGFR1-specific signals

<1.0 × 10–6

1.70 × 10–4

PA164728199†

Integrins in angiogenesis

9.0 × 10–6

(a)

PA164728205†*

S1P1 pathway

8.0 × 10–6

1.1 × 10–5

PA164728223†

HIF-1-alpha transcription factor network

<1.0 × 10–6

1.92 × 10–4

PA164728227†*

Glypican 1 network

1.0 × 10–6

<1.0 × 10–6

PA2032†*

VEGF pathway

<1.0 × 10–6

<1.0 × 10–6


† Pathways (processes) that are significant using the weighted approach.

* Pathways (processes) that are significant using the unweighted approach.

Xing et al. BMC Proceedings 2011 5(Suppl 9):S6   doi:10.1186/1753-6561-5-S9-S6

Open Data