CIM Schroedinger Eigenmaps II Five highly connected genes from Figure 13 were labeled in Schroedinger Eigenmaps. After clustering, all five genes are contained in the same cluster. The GO categories for this cluster match the optic fissure closure and thus provide distinct biological specificity (eye photoreceptor cell development, eye photoreceptor cell differentiation, camera type eye morphogenesis, retina morphogenesis in camera type eye, eye morphogenesis, eye development, sensory organ development). Schroedinger Eigenmaps using labels derived from the Laplacian weight matrix D provide better specificity than using Laplacian Eigenmaps without any labels.
Ehler et al. BMC Proceedings 2011 5(Suppl 2):S3 doi:10.1186/1753-6561-5-S2-S3