Table 5 |
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|
Weighted GRS composed from both SNP and haplotype markersa |
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|
Mean (LDL-C & HDL-C)/median (TG) in GRS by quartiles |
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|
|
|||||||||
|
GRS |
Min |
Max |
Mean |
S.D. |
1 |
2 |
3 |
4 |
p-Value |
|
|
|||||||||
|
GRS-LDL |
-34.8 |
21 |
-1.59 |
7.3 |
|||||
|
LDL-C |
107.7 |
115.2 |
119.1 |
122.7 |
6.0 × 10-28 |
||||
|
HDL-C |
54.3 |
53.5 |
53.2 |
53.2 |
0.22 |
||||
|
TG |
79.0 |
81.0 |
83.0 |
79.0 |
0.055 |
||||
|
GRS-HDL |
-27.0 |
17 |
-1.74 |
3.6 |
|||||
|
LDL-C |
115.7 |
116.4 |
117.2 |
115.5 |
0.53 |
||||
|
HDL-C |
50.5 |
51.7 |
54.9 |
56.9 |
6.2 × 10-25 |
||||
|
TG |
84.0 |
84.5 |
83.0 |
75.0 |
5.6 × 10-8 |
||||
|
GRS-TG |
-32.0 |
31 |
-2.59 |
8.4 |
|||||
|
LDL-C |
114.5 |
118.2 |
116.8 |
116.2 |
0.07 |
||||
|
HDL-C |
55.0 |
53.5 |
52.5 |
52.6 |
4.5 × 10-5 |
||||
|
TG |
72.0 |
81.0 |
85.0 |
90.0 |
6.7 × 10-23 |
||||
|
|
|||||||||
|
aResults of association testing using a linear mixed model with family membership included in the model as a random-effects variable. Phenotype values are in mg/dL |
|||||||||
|
Piccolo et al. BMC Proceedings 2009 3(Suppl 7):S46 |
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