Table 2

Genetic and physical map locations of window region identified using PC-sliding-window analysis based on the Bonferroni correction

Window ID

Chr^a

Physical location

Genes^b

CRASG^c

1

6

30014670, 33187144

TNF, HLA-A HLA-B, HLA-C

TNF, HLA-A HLA-B, HLA-C

2

1

792429, 1101089

AGRN, C1orf159, ISG15, SAMD11

3

2

172768404, 172807000

DLX1, DLX2

STAT4, ITGAV

4

12

46666298, 46718200

COL2A1, LOC728181 LOC728114

5

13

113656958, 113861908

FAM70B, RASA3

6

7

154133201, 154241160

PAXIP1, LOC202781

7

17

68283979, 68361160

SLC39A11

8

2

98261543, 98370780

VWA3B

IL1B

9

13

49336428, 49340230

KPNA3

10

1

2243956, 3359357

ARHGEF16, PRDM16

11

17

66647226, 66750860

Intergenic 17q24

12

16

67482002, 67660490

TMC07, FLJ12331

13

18

75300466, 75314140

NFATC1

14

13

74883232, 74941310

TBC1D4

15

9

123211883, 123248000

CRB2, MIRN601, DENND1A

TRAF1/C5

16

20

57796484, 57832810

17

1

15181683, 151846600

ADAM15, EFNA4

18

20

35438689, 35501280

SRC, RPL7AL4

19

22

28164734, 28237820

RFPL1S, RFPL1, NEFH

20

11

64593946, 64661480

SAC3D1, NAALADL1 CDCA5, ZFPL1, ZHIT2

21

11

45207308, 45314100

SYT13, FLJ41423

22

8

20327035, 20435200

23

5

137614229, 137825000

GFRA3, CDC25C, FAM53C, JMJD1B

24

7

129525353, 129580000

CPA2, CPA4

25

3

134954925, 134966000

TF, SRPRB

26

9

104811123, 104815000

ABCA1

27

12

6924169, 6932652

ATN1, CL2orf57, PTPN6

28

10

10531181, 10542841

SH3PXD2A

29

11

3335218, 3524620

ZNF195, OR7Z12p

30

19

19106771, 19154190

TMEM16A1, MEF2B

^aChr, chromosome

^bWe found the significant genes using the NCBI dbSNP database http://www.ncbi.nlm.nih.gov/sites/entrez?db=snp webcite.

^cThe confirmed RA susceptibility genes (CRASG) are shown in the last column if they are within or near our significant region.

Sha et al. BMC Proceedings 2009 3(Suppl 7):S14