Table 1

Revised nomenclature for N-terminal acetyltransferases

Type

NatA

NatB

NatC

NatD

NatE

Original

Catalytic subunit

Ard1p

Nat3p

Mak3p

Nat4p

Nat5p

Auxiliary subunit

Nat1p

Mdm20p

Mak10p

†

Mak31p

Revised

Catalytic subunit

Naa10p

Naa20p

Naa30p

Naa40p

Naa50p

Auxiliary subunit

Naa15p

Naa25p

Naa35p

†

Naa38p

Number of yeast substrates

~2,000

~1,000

~250

2?

?

Substrates*

Ser-

Met-Glu-

Met-Ile-

Ser-Gly-etc-

?

Ala-

Met-Asp-

Met-Leu-

Gly-

Met-Asn-

Met-Trp-

Thr-

Met-Phe-

Val-‡

Cys-¶

------------2 to 8 amino acids-----------

30–50 a. a

?

Naa50p is inferred to be an N-terminal acetyltransferase because of its sequence homology to known NATs.

* Acetylation occurs at least partially on all proteins with Met-Glu-, Met-Asp- and Met-Asn- termini, but only on subclasses of proteins with the other termini.

† Naa15p may be an auxiliary subunit of NatE, as well as an auxiliary subunit of NatA.

‡ Found in humans but not yeast (see Figure 2 legend).

¶One example found in yeast (see Figure 2 legend).

Polevoda et al. BMC Proceedings 2009 3(Suppl 6):S2   doi:10.1186/1753-6561-3-S6-S2