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This article is part of the supplement: 6th International Symposium on the Intraductal Approach to Breast Cancer

Open Access Meeting abstract

Therapeutic value of a new scarless intervention, ductoscopic papillomectomy, in patients with pathologic nipple discharge

Ö Bender1, FL BalcR2*, E Yüney1 and H Akbulut1

Author Affiliations

1 Department of Surgery, Okmeydanı Training and Research Hospital, Istanbul, Turkey

2 Department of Surgery, Şereflikoçhisar State Hospital, Ankara, Turkey

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BMC Proceedings 2009, 3(Suppl 5):S15  doi:10.1186/1753-6561-3-S5-S15

The electronic version of this article is the complete one and can be found online at:

Published:24 July 2009

© 2009 Bender et al; licensee BioMed Central Ltd.


Efforts have been made to develop new methods to improve the diagnosis of intraductal lesions and their surgical removal. We evaluated the therapeutic value of a new scarless operation, endoscopic papillomectomy, (EP) in patients with pathologic nipple discharge (PND).


Breast ductoscopy was performed on 213 female patients with PND. These patients underwent a variety of appropriate ductoscopy-assisted (DA) endosurgical interventions, combined with cytologic examinations. Success was determined by recurrence of PND and by standard radiological examinations.


Ductoscopy was successfully performed in 178 patients. Of these 178 patients, 34 had solitary papillomas (SP), 8 had multiple papillomas (MP), 19 had intraductal debris and 5 had ductal epithelial surface abnormality with positive cytology. Of the 34 polypoid lesions (cytology negative), 22 were excised endoscopically (endoscopic papillomectomy). Patients with MP underwent DA-microdochectomy. These 42 patients (34 with SP, and 8 with MP) had histopathology results consistent with intraductal papillomas or papillomatosis. Five patients with positive cytology underwent DA-terminal ductal lobular unit excision after their histopathology reports showed had DCIS. Except in one patient, all discharges disappeared. After a mean ± SD follow up time of 14.4 ± 5.2 months (range, 1–27 months), there were no recurrences of nipple discharge and no radiological results suggestive of malignancy. Thus, the therapeutic efficacy of EP in our study was 95.4% (21/22).


Ductoscopy is not only a diagnostic procedure, but is also therapeutic for breast papillomas. EP is a new scarless treatment option for patients with PND (1,2). With technical improvements in ductoscopy and endoscopic sampling instruments, a greater degree of therapeutic efficacy will be achieved.