This article is part of the supplement: Infectious diseases of the nervous system: pathogenesis and worldwide impact

Oral presentation

Axon/myelin traffic of Theiler's virus during persistent CNS infection

Jean-Pierre Roussarie¹, Claude Ruffie¹, Julia M Edgar², Ian Griffiths² and Michel Brahic^1,3

¹Department of Virology, Institut Pasteur, Paris, 75724 Cedex 15, France

²Institute of Comparative Medicine, University of Glasgow, Glasgow, UK

³Department of Microbiology-Immunology, Stanford University, Stanford CA 94305, USA

author email corresponding author email

from Infectious diseases of the nervous system: pathogenesis and worldwide impact
Paris, France. 10–13 September 2008

BMC Proceedings 2008, 2(Suppl 1):S38

Published:	23 September 2008

First paragraph (this article has no abstract)

Theiler's virus, a murine picornavirus, persists for life in the central nervous system (CNS) of mouse and causes a demyelinating disease, which is a model for multiple sclerosis. The virus infects neurons first but persists in white matter glial cells, mainly in oligodendrocytes and macrophages. The mechanism by which the virus traffics from neurons to glial cells and the respectives roles of oligodendrocytes and macrophages in persistence are poorly understood.