• Top
• Background
• Methods
• Results
• Conclusion

This article is part of the supplement: Infectious diseases of the nervous system: pathogenesis and worldwide impact .

Poster presentation

Non-invasive intracranial pressure monitoring in African children with infectious encephalopathies: preliminary results

Samson Gwer¹ , Richard Idro^1,2, Michael Kazungu¹, Edwin Chengo¹, Mwanamvua Boga¹, Eric Ohuma¹, Kathryn Maitland^1,3, Tony Birch⁴, Robert Marchbanks⁴, Fenella Kirkham^5,6 and Charles Newton^1,6

¹Centre for Geographic Medicine Research, Kenya Medical Research Institute, Kilifi, Kenya

²Department of Paediatrics and Child Health, Mulago Hospital/Makerere University Medical School, Kampala, Uganda

³Department of Paediatrics, Imperial College, London, UK

⁴Neurological Physics Group, Department of Medical Physics, Southampton University Hospitals NHS Trust, Southampton, UK

⁵Clinical Neurosciences, Southampton University, Southampton, UK

⁶Neurosciences Unit, Child Health Institute, University of London, London, UK

author email corresponding author email

from Infectious diseases of the nervous system: pathogenesis and worldwide impact
Paris, France. 10–13 September 2008

BMC Proceedings 2008, 2(Suppl 1):P24

The electronic version of this abstract is the complete one and can be found online at: http://www.biomedcentral.com/1753-6561/2/S1/P24

Published:

23 September 2008

© 2008 Gwer et al; licensee BioMed Central Ltd.

Background

Infectious encephalopathies due to cerebral malaria (CM), Acute Bacterial Meningitis (ABM) and Viral Encephalitis are an important cause of pediatric morbidity in sub-Saharan Africa. Raised intracranial pressure (ICP) occurs in all of these encephalopathies and is associated with an increased risk of death and neurological sequelae. Non-invasive tools for measuring ICP allow for serial and yet safe monitoring and enable early recognition of raised ICP. Such observations could also provide further insight into the pathophysiology of these diseases.

Methods

Children presenting with coma at the Kilifi District Hospital were recruited for non-invasive ICP monitoring using the Tympanic Membrane Displacement Analyser (TMD) and for measurements of right middle cerebral artery blood flow using the Trans-cranial Doppler machine (TCD). Measurements were taken at 0, 4 and 24 hours and thereafter, every 24 hours for a maximum of 72 hours or until the patients regained full consciousness. Measurements were also taken at lumbar puncture (LP), when LP manometry was also performed. Neurological sequelae were assessed for at discharge.

Results

Twenty-two children (15 male) with a median age of 45 (range 12 – 144) months were monitored. Fifteen had CM, 5 ABM and 2 sepsis; Staphylococcus aureus and Salmonella typhi. Five children died and five had gross neurological sequelae at discharge. The median admission TMD peak to peak (P-P) intra-aural pressure measurements in children who died was 276 (range 241–518)nl compared to 121(58–410)nl in those who survived(p = 0.05; Mann-Whitney test). A P-P admission reading ≥300 nl was significantly associated with death or neurological sequelae (relative risk 2.5, 95% C.I. 1.2–5.4, p = 0.04). A positive correlation was observed between P-P readings and TCD pulsatility indices (r = 0.423). Baseline pressure waves were not analysed since most children had abnormal tympanometry.

Conclusion

The TMD appears to be of value in determining prognosis. It may also be useful in monitoring intracranial pressure but more observations are needed to confirm this.

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