Table 1

Distribution of selected clinical characteristics among study participants from rheumatoid arthritis studies for GAW15 Problem 2

Study source

US Microsa

US-SNPsb

Canada Affymetrix

Canada Illuminac

France

UK Cohort 1d

UK Cohort 2e


Ascertainment criteria

2 ACR+ sibs, 1 with erosions

2 ACR+ sibs, 1 with erosions

2 ACR+ sibs

2 ACR+ sibs

2 ACR+ sibs

2 ACR+ sibs


Number of families

511

757

79

60

88

174

195

Affected sibs/family

2.13

2.15

2

2

2.18

2.13

2.09

% SE+

71%

79%

N/A

N/A

N/A

90%

82%

% Erosion

95%

97%

39%

N/A

N/A

76%

71%

Median age onset

39.1

38.9

43.8

N/A

N/A

39.3

44.0

% RF+

81.1%

74.3%

71.1%

N/A

N/A

62.5%

56.7%


aNumbers from Jawaheer et al. [17]. One family was eliminated from GAW15 data because one sib did not meet ACR criteria for RA.

bOf these families, 9 had only phenotype information and no SNP genotypes, 509 families have both SNP and microsatellite data, 2 families have microsatellite data only, and 237 have SNP data only.

c47 families have genotype data using both Affymetrix and Illumina platforms.

d174 affected families had microsatellite data and of these 157 also had SNP genotyping.

eSelected microsatellite markers were genotyped for variable numbers of these families.

Amos et al. BMC Proceedings 2007 1(Suppl 1):S3  

Open Data