Table 1

Distribution of selected clinical characteristics among study participants from rheumatoid arthritis studies for GAW15 Problem 2

Study source

US Micros^a

US-SNPs^b

Canada Affymetrix

Canada Illumina^c

France

UK Cohort 1^d

UK Cohort 2^e

Ascertainment criteria

2 ACR+ sibs, 1 with erosions

2 ACR+ sibs, 1 with erosions

2 ACR+ sibs

2 ACR+ sibs

2 ACR+ sibs

2 ACR+ sibs

Number of families

511

757

79

60

88

174

195

Affected sibs/family

2.13

2.15

2

2

2.18

2.13

2.09

% SE+

71%

79%

N/A

N/A

N/A

90%

82%

% Erosion

95%

97%

39%

N/A

N/A

76%

71%

Median age onset

39.1

38.9

43.8

N/A

N/A

39.3

44.0

% RF+

81.1%

74.3%

71.1%

N/A

N/A

62.5%

56.7%

^aNumbers from Jawaheer et al. [17]. One family was eliminated from GAW15 data because one sib did not meet ACR criteria for RA.

^bOf these families, 9 had only phenotype information and no SNP genotypes, 509 families have both SNP and microsatellite data, 2 families have microsatellite data only, and 237 have SNP data only.

^c47 families have genotype data using both Affymetrix and Illumina platforms.

^d174 affected families had microsatellite data and of these 157 also had SNP genotyping.

^eSelected microsatellite markers were genotyped for variable numbers of these families.

Amos et al. BMC Proceedings 2007 1(Suppl 1):S3