Figure 1.

TDT tests for mother-daughter transmissions, restricted to mothers with DR genotype 1/1. a, TDT for three subsets separately. Dotted vertical line indicates the location of DR locus. b, TDT scores using sub-sample A (square) versus imputed scores (line). c, TDT scores assuming all markers are genotyped in each individual (TDT_all), open square) versus TDT_comb. Dotted line indicates 0.01 critical value for TDT_all, and solid line represents the corresponding critical value for TDT_comb. d, Comparison of TDT_all and TDT_comb after a quantile transformation.