Table 3 |
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|
Performance of the multiple-marker strategy in disease severity analysis |
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|
Correction for multiple testing |
FBAT LC |
% of severity loci detectedb |
||
|
|
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|
Sensitivitya |
Specificitya |
FDRa |
||
|
|
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|
Without correction |
1.00 (0.00) |
0.92 (0.03) |
0.75 (0.13) |
0.91 (0.19) |
|
Benjamini & Hochberg |
0.96 (0.20) |
0.99 (0.01) |
0.14 (0.24) |
0.87 (0.26) |
|
Bonferroni |
0.96 (0.20) |
0.99 (0.01) |
0.14 (0.24) |
0.87 (0.26) |
|
|
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|
aMean (standard deviation) of sensitivity, specificity and false-discovery rate of FBAT-LC test computed over 50 replicates of family data when 50 regions were selected in Step 1. bMean (standard deviation) of the proportion of severity loci selected in Step 1 and detected in Step 2 by FBAT at the 5% level over 50 replicates when 50 regions were selected in Step 1. |
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|
Aschard et al. BMC Proceedings 2007 1(Suppl 1):S134 |
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