Table 3

Significant SNP epistasis effects on square root transformed anti-CCP with p < 10-7
Chromosome 1
 SNP1
 Chromosome 2
 SNP2
 Effecta
 p-Value
1
 rs2031750
 18
 rs1395610
 A × A
 0.827 × 10-7
2
 rs1261238
 23
 rs953114
 D × A
 0.976 × 10-7






6
 rs310389
 13
 rs4941527
 I
 0.563 × 10-7
6
 rs310389
 13
 rs4941527
 D × A
 0.765 × 10-7






6
 rs873460
 16
 rs874562
 A × A
 0.754 × 10-7
6
 rs1087924
 23
 rs644429
 I
 0.583 × 10-7
7
 rs2056553
 10
 rs1328327
 D × A
 0.583 × 10-8






11
 rs1009172
 23
 rs17410
 I
 0.612 × 10-9
11
 rs1009172
 23
 rs17410
 A × A
 0.247 × 10-10
12
 rs1400142
 14
 rs1959068
 D × D
 0.437 × 10-7

aI, two-locus interaction effect; A × A, additive × additive effect; A × D, additive × dominance effect; D × A, dominance × additive effect; D × D, dominance × dominance effect.

Ma et al. BMC Proceedings 2007 1(Suppl 1):S127