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Signaling dynamics of palmitate-induced ER stress responses mediated by ATF4 in HepG2 cells

Hyunju Cho1, Ming Wu2, Linxia Zhang1, Ryan Thompson3, Aritro Nath4 and Christina Chan12345*

Author Affiliations

1 Department of Chemical Engineering and Materials Science, East Lansing, MI 48824, USA

2 Department of Computer Science and Engineering, East Lansing, MI 48824, USA

3 Cell and Molecular Biology Program, East Lansing, MI, 48824, USA

4 Genetics program, East Lansing, MI, 48824, USA

5 Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, 48824, USA

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BMC Systems Biology 2013, 7:9  doi:10.1186/1752-0509-7-9

Published: 22 January 2013

Additional files

Additional file 1:

Contains experimental and computational simulation results: Figure S1. The protein expression levels of PKAc (PKA catalytic subunits) upon palmitate treatment, Figure S2. The protein expression levels of PP1 upon palmitate treatment, Figure S3. In silico knock-out of signaling pathways for CREB1 activation, Figure S4. Simulation of the discrete dynamic model with different amount of independent sampling size. (DOCX 763 kb)

Format: DOCX Size: 763KB Download file

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