Figure 11.

Model selection scheme. Model selection scheme: Local sensitivity analysis and identifiability analysis allowed to reduce Model I leading to Model II. Subsequently, new hypotheses and model selection and identification via MINLP were conducted to formulate Model III. The identifiability of Model III was assessed by means of a pseudo-global sensitivity approach and correlation analysis indicating that no further modifications were required.

Rodriguez-Fernandez et al. BMC Systems Biology 2013 7:76   doi:10.1186/1752-0509-7-76
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