Table 7 |
||
Strongly connected phenotype-model parameter pairs | ||
Phenotype | Perturbed model parameter | Probability of phenotype loss |
cdc15 Δ net1-ts cdh1 Δ | Total amount of Cdc14 | 1.00 |
cdc15 Δ net1-ts cdh1 Δ | Total amount of Net1 | 0.99 |
CLB2-db Δ multicopy SIC1 | Basal SBF dephosphorylation | 0.93 |
CLB2-db Δ multicopy SIC1 | SBF-dependent Cln2 synthesis | 0.90 |
cln1,2 Δ cdh1 Δ GAL-CLN2 | Total amount of Esp1 | 0.89 |
CLB2-db Δ multicopy SIC1 | CKI phosphorylation rate | 0.88 |
cdc15 Δ net1-ts cdh1 Δ | Efficiency of Cdc14-Net1 complex (RENT) formation | 0.88 |
cln1,2 Δ cdh1 Δ GAL-CLN2 | PPX inactivation by Esp1 | 0.87 |
GALL-CDC20 sic1 Δ cdh1 Δ | Degradation rate of Cdc20 | 0.87 |
cdc15-ts multicopy CDC14 | Total amount of Net1 | 0.87 |
Upon a perturbation, with at least 0.87 probability, these parameters caused the loss of the corresponding phenotype (all phenotypes are experimentally viable).
Oguz et al.
Oguz et al. BMC Systems Biology 2013 7:53 doi:10.1186/1752-0509-7-53