Table 2

Parameters defined in the model
Parameter Definition Value Reference
Synthesis, dimension =/hour
sime1 Synthesis rate of Ime1 10 [15,43-45]
sime2 Synthesis rate of Ime2 10 [39]
sime2 The maximum rate of auto-regulation-dependent Ime2 synthesis 3 Estimated
Degradation, dimension =/hour
dime1 Degradation rate of Ime1 1 [3]
dime1 The maximum rate of Ime2-activated Ime1 degradation 1 [3]
dpime1 Degradation rate of pIme1 1 [3]
dime2 Degradation rate of Ime2 8 [3]
Phosphorylation, dimension =/hour
prim11 Phosphorylation rate of Rim11 0.01 [2], Estimated
urim11 Dephosphorylation rate of Rim11 0.1 [2], Estimated
pume6 Phosphorylation rate of Ume6 0.3 [18], Estimated
uume6 Dephosphorylation rate of Ume6 0.01 [18], Estimated
psok2 Phosphorylation rate of Sok2 0.7 [6], Estimated
usok2 Dephosphorylation rate of Sok2 1 [6], Estimated
pime1 Phosphorylation rate of Ime1 2 Estimated
Constant, dimensionless
csok2 Constant measuring half-maximum inhibition of Sok2 phosphorylation by Ime1 0.05 Estimated
cime1 Constant measuring half-maximum inhibition of Ime1 synthesis by pSok2 0.01 Estimated
c1 Constant measuring half-maximum activation of Ime1 degradation by Ime2 0.01 Estimated
c2 Constant measuring half-maximum activation of Ime2 synthesis through auto-regulation 1.4 Estimated
c3 Constant measuring half-maximum activation of Ime2 degradation 2 Estimated

Ray et al.

Ray et al. BMC Systems Biology 2013 7:37   doi:10.1186/1752-0509-7-37

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