Figure 5.

Simulation analyses of double-negative feedback loop between pSok2 and Ime1. A) Ime1 and Ime2 dynamics when varying cime1, the constant measuring half-maximum inhibition of Ime1 synthesis by pSok2. Red curve: cime1 = ∞ (deleting the inhibition); cyan curve: cime1 = 0.1 (decreasing the inhibition); blue curve: cime1 = 0.001 (increasing the inhibition); green curve: cime1 = 0.01 (baseline value). B) Ime1 and Ime2 dynamics when varying csok2, the constant measuring half-maximum inhibition of Sok2 phosphorylation by Ime1. Red curve: csok2 = ∞ (deleting the inhibition); cyan curve: csok2 = 0.5 (decreasing the inhibition); blue curve: csok2 = 0.005 (increasing the inhibition); green curve: csok2 = 0.05 (baseline value). C) Ime1 and Ime2 dynamics when varying cime1 and csok2 simultaneously. Red curve: cime1 = ∞ and csok2 = ∞ (deleting the feedback loop); cyan curve: cime1 = 0.1 and csok2 = 0.5 (decreasing the feedback loop); blue curve: cime1 = 0.001 and csok2 = 0.005 (increasing the feedback loop); green curve: cime1 = 0.01 and csok2 = 0.05 (baseline value). The mathematical model of the feedback knockout is described in Additional file 2: Table S6.

Ray et al. BMC Systems Biology 2013 7:37   doi:10.1186/1752-0509-7-37
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