Resolution:
## Figure 5.
Simulation analyses of double-negative feedback loop between pSok2 and Ime1. A) Ime1 and Ime2 dynamics when varying c_{ime1}, the constant measuring half-maximum inhibition of Ime1 synthesis by pSok2. Red curve:
c_{ime1} = ∞ (deleting the inhibition); cyan curve: c_{ime1} = 0.1 (decreasing the inhibition); blue curve: c_{ime1} = 0.001 (increasing the inhibition); green curve: c_{ime1} = 0.01 (baseline value). B) Ime1 and Ime2 dynamics when varying c_{sok2}, the constant measuring half-maximum inhibition of Sok2 phosphorylation by Ime1.
Red curve: c_{sok2} = ∞ (deleting the inhibition); cyan curve: c_{sok2} = 0.5 (decreasing the inhibition); blue curve: c_{sok2} = 0.005 (increasing the inhibition); green curve: c_{sok2} = 0.05 (baseline value). C) Ime1 and Ime2 dynamics when varying c_{ime1} and c_{sok2} simultaneously. Red curve: c_{ime1} = ∞ and c_{sok2} = ∞ (deleting the feedback loop); cyan curve: c_{ime1} = 0.1 and c_{sok2} = 0.5 (decreasing the feedback loop); blue curve: c_{ime1} = 0.001 and c_{sok2} = 0.005 (increasing the feedback loop); green curve: c_{ime1} = 0.01 and c_{sok2} = 0.05 (baseline value). The mathematical model of the feedback knockout is described
in Additional file 2: Table S6.
Ray |